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Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine
Yangtao Wu, Shaojuan Wang, Yali Zhang, Lunzhi Yuan, Qingbing Zheng, Min Wei, Yang Shi, Zikang Wang, Jian Ma, Kai Wang, Meifeng Nie, Jin Xiao, Zehong Huang, Peiwen Chen, Huilin Guo, Miaolin Lan, Jingjing Xu, Wangheng Hou, Yunda Hong, Dabing Chen, Hui Sun, Hualong Xiong, Ming Zhou, Che Liu, Wenjie Guo, Huiyu Guo, Jiahua Gao, Zhixiong Li, Haitao Zhang, Xinrui Wang, Shaowei Li, Tong Cheng, Qinjian Zhao, Yixin Chen, Ting Wu, Tianying Zhang, Jun Zhang, Hua Cao, Huachen Zhu, Quan Yuan, Yi Guan, Ningshao Xia
doi: https://doi.org/10.1101/2022.01.25.477789
Yangtao Wu
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Shaojuan Wang
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Yali Zhang
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Lunzhi Yuan
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Qingbing Zheng
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Min Wei
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Yang Shi
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Zikang Wang
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Jian Ma
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Kai Wang
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Meifeng Nie
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Jin Xiao
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Zehong Huang
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Peiwen Chen
2State Key Laboratory of Emerging Infectious Diseases, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P. R. China
3Guangdong-Hong Kong Joint Laboratory of Emerging Infectious Diseases/Joint Laboratory for International Collaboration in Virology and Emerging Infectious Diseases, Joint Institute of Virology (STU/HKU), Shantou University, Shantou, Guangdong, 515063, P. R. China
4EKIH Pathogen Research Institute, Futian District, Shenzhen, Guangdong, 518045, P. R. China
Huilin Guo
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Miaolin Lan
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Jingjing Xu
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Wangheng Hou
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Yunda Hong
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Dabing Chen
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Hui Sun
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Hualong Xiong
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Ming Zhou
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Che Liu
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Wenjie Guo
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Huiyu Guo
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Jiahua Gao
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Zhixiong Li
5Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate, National Health Commission, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350013, Fujian, P. R. China
Haitao Zhang
5Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate, National Health Commission, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350013, Fujian, P. R. China
Xinrui Wang
5Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate, National Health Commission, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350013, Fujian, P. R. China
Shaowei Li
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Tong Cheng
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Qinjian Zhao
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Yixin Chen
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Ting Wu
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Tianying Zhang
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Jun Zhang
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Hua Cao
5Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate, National Health Commission, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350013, Fujian, P. R. China
Huachen Zhu
2State Key Laboratory of Emerging Infectious Diseases, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P. R. China
3Guangdong-Hong Kong Joint Laboratory of Emerging Infectious Diseases/Joint Laboratory for International Collaboration in Virology and Emerging Infectious Diseases, Joint Institute of Virology (STU/HKU), Shantou University, Shantou, Guangdong, 515063, P. R. China
4EKIH Pathogen Research Institute, Futian District, Shenzhen, Guangdong, 518045, P. R. China
Quan Yuan
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
Yi Guan
2State Key Laboratory of Emerging Infectious Diseases, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P. R. China
3Guangdong-Hong Kong Joint Laboratory of Emerging Infectious Diseases/Joint Laboratory for International Collaboration in Virology and Emerging Infectious Diseases, Joint Institute of Virology (STU/HKU), Shantou University, Shantou, Guangdong, 515063, P. R. China
4EKIH Pathogen Research Institute, Futian District, Shenzhen, Guangdong, 518045, P. R. China
Ningshao Xia
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
6Research Unit of Frontier Technology of Structural Vaccinology, Chinese Academy of Medical Sciences, Xiamen 361102, Fujian, P. R. China
Article Information
History
- January 26, 2022.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Author Information
- Yangtao Wu1,†,
- Shaojuan Wang1,†,
- Yali Zhang1,†,
- Lunzhi Yuan1,†,
- Qingbing Zheng1,†,
- Min Wei1,†,
- Yang Shi1,†,
- Zikang Wang1,
- Jian Ma1,
- Kai Wang1,
- Meifeng Nie1,
- Jin Xiao1,
- Zehong Huang1,
- Peiwen Chen2,3,4,
- Huilin Guo1,
- Miaolin Lan1,
- Jingjing Xu1,
- Wangheng Hou1,
- Yunda Hong1,
- Dabing Chen1,
- Hui Sun1,
- Hualong Xiong1,
- Ming Zhou1,
- Che Liu1,
- Wenjie Guo1,
- Huiyu Guo1,
- Jiahua Gao1,
- Zhixiong Li5,
- Haitao Zhang5,
- Xinrui Wang5,
- Shaowei Li1,
- Tong Cheng1,
- Qinjian Zhao1,
- Yixin Chen1,
- Ting Wu1,
- Tianying Zhang1,*,
- Jun Zhang1,*,
- Hua Cao5,*,
- Huachen Zhu2,3,4,*,
- Quan Yuan1,*,
- Yi Guan2,3,4,* and
- Ningshao Xia1,6,*
- 1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health & School of Life Sciences, Xiamen University, Xiamen 361102, P. R. China
- 2State Key Laboratory of Emerging Infectious Diseases, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P. R. China
- 3Guangdong-Hong Kong Joint Laboratory of Emerging Infectious Diseases/Joint Laboratory for International Collaboration in Virology and Emerging Infectious Diseases, Joint Institute of Virology (STU/HKU), Shantou University, Shantou, Guangdong, 515063, P. R. China
- 4EKIH Pathogen Research Institute, Futian District, Shenzhen, Guangdong, 518045, P. R. China
- 5Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate, National Health Commission, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350013, Fujian, P. R. China
- 6Research Unit of Frontier Technology of Structural Vaccinology, Chinese Academy of Medical Sciences, Xiamen 361102, Fujian, P. R. China
- ↵*Corresponding author. Email: zhangtianying{at}xmu.edu.cn (T. Z.), zhangj{at}xmu.edu.cn (J. Z.), zhuhch{at}hku.hk (H. Z.), caohua69{at}fjmu.edu.cn (H. C.), yuanquan{at}xmu.edu.cn (Q. Y.), yguan{at}hku.hk (Y. G.), nsxia{at}xmu.edu.cn (N. X.)
↵† These authors contributed equally to this work.
Posted January 26, 2022.
Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine
Yangtao Wu, Shaojuan Wang, Yali Zhang, Lunzhi Yuan, Qingbing Zheng, Min Wei, Yang Shi, Zikang Wang, Jian Ma, Kai Wang, Meifeng Nie, Jin Xiao, Zehong Huang, Peiwen Chen, Huilin Guo, Miaolin Lan, Jingjing Xu, Wangheng Hou, Yunda Hong, Dabing Chen, Hui Sun, Hualong Xiong, Ming Zhou, Che Liu, Wenjie Guo, Huiyu Guo, Jiahua Gao, Zhixiong Li, Haitao Zhang, Xinrui Wang, Shaowei Li, Tong Cheng, Qinjian Zhao, Yixin Chen, Ting Wu, Tianying Zhang, Jun Zhang, Hua Cao, Huachen Zhu, Quan Yuan, Yi Guan, Ningshao Xia
bioRxiv 2022.01.25.477789; doi: https://doi.org/10.1101/2022.01.25.477789
Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine
Yangtao Wu, Shaojuan Wang, Yali Zhang, Lunzhi Yuan, Qingbing Zheng, Min Wei, Yang Shi, Zikang Wang, Jian Ma, Kai Wang, Meifeng Nie, Jin Xiao, Zehong Huang, Peiwen Chen, Huilin Guo, Miaolin Lan, Jingjing Xu, Wangheng Hou, Yunda Hong, Dabing Chen, Hui Sun, Hualong Xiong, Ming Zhou, Che Liu, Wenjie Guo, Huiyu Guo, Jiahua Gao, Zhixiong Li, Haitao Zhang, Xinrui Wang, Shaowei Li, Tong Cheng, Qinjian Zhao, Yixin Chen, Ting Wu, Tianying Zhang, Jun Zhang, Hua Cao, Huachen Zhu, Quan Yuan, Yi Guan, Ningshao Xia
bioRxiv 2022.01.25.477789; doi: https://doi.org/10.1101/2022.01.25.477789
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