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Endogenous pancreatic microRNAs differentially target the Delta, Omicron, and Wuhan SARS-CoV-2 genomes to upregulate the Diabetes-associated genes

Bhavya Bhavya, View ORCID ProfileEkta Pathak, View ORCID ProfileRajeev Mishra
doi: https://doi.org/10.1101/2022.01.26.477612
Bhavya Bhavya
1Bioinformatics Department, MMV, Institute of Science, Banaras Hindu University, Varanasi, India
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Ekta Pathak
1Bioinformatics Department, MMV, Institute of Science, Banaras Hindu University, Varanasi, India
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  • ORCID record for Ekta Pathak
Rajeev Mishra
1Bioinformatics Department, MMV, Institute of Science, Banaras Hindu University, Varanasi, India
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  • For correspondence: rajeev17@bhu.ac.in
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Abstract

The SARS-CoV-2 viral genome is mutating and evolving into new variations, including the recently discovered Delta and Omicron. In this study, we used and evaluated our notion of differential targeting of SARS-CoV-2 variant genomes by microRNAs (miRNAs) of the infected human pancreas. We found that even with UTR mutations, the Delta, Omicron, and original Wuhan variations’ genomes would be differentially targeted by the host pancreas cell’s native miRNAs in the same way. The miRNAs show a difference in Minimal Free Energy (MFE) with the different viral variants’ genomes; however, they would still be responsible for the upregulation of the diabetes-associated genes.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵2 Varanasi, Uttar Pradesh, 221005, India

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted January 28, 2022.
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Endogenous pancreatic microRNAs differentially target the Delta, Omicron, and Wuhan SARS-CoV-2 genomes to upregulate the Diabetes-associated genes
Bhavya Bhavya, Ekta Pathak, Rajeev Mishra
bioRxiv 2022.01.26.477612; doi: https://doi.org/10.1101/2022.01.26.477612
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Endogenous pancreatic microRNAs differentially target the Delta, Omicron, and Wuhan SARS-CoV-2 genomes to upregulate the Diabetes-associated genes
Bhavya Bhavya, Ekta Pathak, Rajeev Mishra
bioRxiv 2022.01.26.477612; doi: https://doi.org/10.1101/2022.01.26.477612

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