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The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition
Michael D Sacco, Yanmei Hu, Maura V Gongora, Flora Meilleur, M Trent Kemp, Xiujun Zhang, Jun Wang, Yu Chen
doi: https://doi.org/10.1101/2022.01.26.477774
Michael D Sacco
1Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, United States
Yanmei Hu
2Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ, 08854, United States
Maura V Gongora
1Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, United States
Flora Meilleur
3Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37830, United States
M Trent Kemp
1Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, United States
Xiujun Zhang
1Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, United States
Jun Wang
2Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ, 08854, United States
Yu Chen
1Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, United States
Posted January 27, 2022.
The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition
Michael D Sacco, Yanmei Hu, Maura V Gongora, Flora Meilleur, M Trent Kemp, Xiujun Zhang, Jun Wang, Yu Chen
bioRxiv 2022.01.26.477774; doi: https://doi.org/10.1101/2022.01.26.477774
The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition
Michael D Sacco, Yanmei Hu, Maura V Gongora, Flora Meilleur, M Trent Kemp, Xiujun Zhang, Jun Wang, Yu Chen
bioRxiv 2022.01.26.477774; doi: https://doi.org/10.1101/2022.01.26.477774
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