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Anti-SARS-CoV-2 swine glyco-humanized polyclonal antibody XAV-19 retains neutralizing activity against SARS-CoV-2 B.1.1.529 (Omicron)

View ORCID ProfileBernard Vanhove, Stéphane Marot, Gwénaëlle Evanno, Isabelle Malet, Gaëtane Rouvray, Françoise Shneiker, Edwige Mevel, Carine Ciron, Juliette Rousse, Pierre-Joseph Royer, Elsa Lheriteau, François Raffi, Odile Duvaux, Anne-Geneviève Marcelin, Vincent Calvez
doi: https://doi.org/10.1101/2022.01.26.477856
Bernard Vanhove
1Xenothera, Nantes, France
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  • For correspondence: Bernard.vanhove@xenothera.com
Stéphane Marot
2Sorbonne Université, INSERM 1136, Institut Pierre Louis d’Epidémiologie et de Santé Publique (iPLESP), Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié Salpêtrière Hospital, Department of Virology, Paris, France
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Gwénaëlle Evanno
1Xenothera, Nantes, France
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Isabelle Malet
2Sorbonne Université, INSERM 1136, Institut Pierre Louis d’Epidémiologie et de Santé Publique (iPLESP), Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié Salpêtrière Hospital, Department of Virology, Paris, France
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Gaëtane Rouvray
1Xenothera, Nantes, France
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Françoise Shneiker
1Xenothera, Nantes, France
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Edwige Mevel
1Xenothera, Nantes, France
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Carine Ciron
1Xenothera, Nantes, France
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Juliette Rousse
1Xenothera, Nantes, France
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Pierre-Joseph Royer
1Xenothera, Nantes, France
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Elsa Lheriteau
1Xenothera, Nantes, France
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François Raffi
3Department of Infectious Disease, Nantes University Hospital, Nantes, France
4INSERM CIC1413, Nantes University Hospital, Nantes, France
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Odile Duvaux
1Xenothera, Nantes, France
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Anne-Geneviève Marcelin
2Sorbonne Université, INSERM 1136, Institut Pierre Louis d’Epidémiologie et de Santé Publique (iPLESP), Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié Salpêtrière Hospital, Department of Virology, Paris, France
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Vincent Calvez
2Sorbonne Université, INSERM 1136, Institut Pierre Louis d’Epidémiologie et de Santé Publique (iPLESP), Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié Salpêtrière Hospital, Department of Virology, Paris, France
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Abstract

B.1.1.529 is the SARS-CoV-2 variant designated Omicron by the WHO in November 2021. It is a highly divergent variant with a high number of mutations, including 26-32 mutations in the spike protein among which 15 in the Receptor Binding Domain (RBD) including at the human angiotensin converting enzyme 2 (ACE-2) receptor interacting interface. Because of a decreased affinity for the ACE-2 receptor and a geometric reorganization of the S1-S2 cleavage site, the Omicron variant is predicted to not have a significant infectivity advantage over the delta variant and to be less pathogenic than Delta. However, in Omicron, neutralizing epitopes are greatly affected, suggesting that current vaccines and neutralizing monoclonal antibodies might confer reduced protection against this variant. In contrast, we and others previously demonstrated that polyclonal antibodies against SARS-CoV-2 RBD obtained from hyperimmunized animal hosts do maintain their neutralizing properties against Alpha to Delta. Here, we confirmed these findings by showing that XAV-19, a swine glyco-humanized polyclonal antibody retains full neutralizing activity against Omicron.

Competing Interest Statement

The authors of this manuscript have conflicts of interest to disclose: BV, GE, GR, FS, EM, CC, JR, PJR, EL, OD are employees of Xenothera, a company developing glyco-humanized polyclonal antibodies as those described in this manuscript.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted January 26, 2022.
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Anti-SARS-CoV-2 swine glyco-humanized polyclonal antibody XAV-19 retains neutralizing activity against SARS-CoV-2 B.1.1.529 (Omicron)
Bernard Vanhove, Stéphane Marot, Gwénaëlle Evanno, Isabelle Malet, Gaëtane Rouvray, Françoise Shneiker, Edwige Mevel, Carine Ciron, Juliette Rousse, Pierre-Joseph Royer, Elsa Lheriteau, François Raffi, Odile Duvaux, Anne-Geneviève Marcelin, Vincent Calvez
bioRxiv 2022.01.26.477856; doi: https://doi.org/10.1101/2022.01.26.477856
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Anti-SARS-CoV-2 swine glyco-humanized polyclonal antibody XAV-19 retains neutralizing activity against SARS-CoV-2 B.1.1.529 (Omicron)
Bernard Vanhove, Stéphane Marot, Gwénaëlle Evanno, Isabelle Malet, Gaëtane Rouvray, Françoise Shneiker, Edwige Mevel, Carine Ciron, Juliette Rousse, Pierre-Joseph Royer, Elsa Lheriteau, François Raffi, Odile Duvaux, Anne-Geneviève Marcelin, Vincent Calvez
bioRxiv 2022.01.26.477856; doi: https://doi.org/10.1101/2022.01.26.477856

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