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Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms
Julia M. Flynn, Neha Samant, Gily Schneider-Nachum, David T. Barkan, Nese Kurt Yilmaz, Celia A. Schiffer, Stephanie A. Moquin, Dustin Dovala, Daniel N.A. Bolon
doi: https://doi.org/10.1101/2022.01.26.477860
Julia M. Flynn
1Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA
Neha Samant
1Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA
Gily Schneider-Nachum
1Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA
David T. Barkan
2Novartis Institutes for Biomedical Research, Emeryville, CA 94608, USA
Nese Kurt Yilmaz
1Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA
Celia A. Schiffer
1Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA
Stephanie A. Moquin
2Novartis Institutes for Biomedical Research, Emeryville, CA 94608, USA
Dustin Dovala
2Novartis Institutes for Biomedical Research, Emeryville, CA 94608, USA
Daniel N.A. Bolon
1Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA
Posted January 30, 2022.
Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms
Julia M. Flynn, Neha Samant, Gily Schneider-Nachum, David T. Barkan, Nese Kurt Yilmaz, Celia A. Schiffer, Stephanie A. Moquin, Dustin Dovala, Daniel N.A. Bolon
bioRxiv 2022.01.26.477860; doi: https://doi.org/10.1101/2022.01.26.477860
Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms
Julia M. Flynn, Neha Samant, Gily Schneider-Nachum, David T. Barkan, Nese Kurt Yilmaz, Celia A. Schiffer, Stephanie A. Moquin, Dustin Dovala, Daniel N.A. Bolon
bioRxiv 2022.01.26.477860; doi: https://doi.org/10.1101/2022.01.26.477860
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