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Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types
View ORCID ProfileMethodios Ximerakis, View ORCID ProfileKristina M. Holton, View ORCID ProfileRichard M. Giadone, View ORCID ProfileCeren Ozek, View ORCID ProfileMonika Saxena, View ORCID ProfileSamara Santiago, View ORCID ProfileXian Adiconis, View ORCID ProfileDanielle Dionne, View ORCID ProfileLan Nguyen, View ORCID ProfileKavya M. Shah, View ORCID ProfileJill M. Goldstein, View ORCID ProfileCaterina Gasperini, View ORCID ProfileScott L. Lipnick, View ORCID ProfileSean K. Simmons, View ORCID ProfileSean M. Buchanan, View ORCID ProfileAmy J. Wagers, View ORCID ProfileAviv Regev, View ORCID ProfileJoshua Z. Levin, View ORCID ProfileLee L. Rubin
doi: https://doi.org/10.1101/2022.01.27.477911
Methodios Ximerakis
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
2Harvard Stem Cell Institute, Cambridge, MA 02138, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge MA 02142, USA
Kristina M. Holton
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
2Harvard Stem Cell Institute, Cambridge, MA 02138, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge MA 02142, USA
Richard M. Giadone
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
2Harvard Stem Cell Institute, Cambridge, MA 02138, USA
Ceren Ozek
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
2Harvard Stem Cell Institute, Cambridge, MA 02138, USA
Monika Saxena
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
2Harvard Stem Cell Institute, Cambridge, MA 02138, USA
Samara Santiago
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
2Harvard Stem Cell Institute, Cambridge, MA 02138, USA
Xian Adiconis
3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge MA 02142, USA
4Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Danielle Dionne
4Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Lan Nguyen
4Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Kavya M. Shah
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
2Harvard Stem Cell Institute, Cambridge, MA 02138, USA
Jill M. Goldstein
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
2Harvard Stem Cell Institute, Cambridge, MA 02138, USA
Caterina Gasperini
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
2Harvard Stem Cell Institute, Cambridge, MA 02138, USA
Scott L. Lipnick
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
2Harvard Stem Cell Institute, Cambridge, MA 02138, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge MA 02142, USA
Sean K. Simmons
3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge MA 02142, USA
4Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Sean M. Buchanan
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
2Harvard Stem Cell Institute, Cambridge, MA 02138, USA
Amy J. Wagers
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
2Harvard Stem Cell Institute, Cambridge, MA 02138, USA
5Joslin Diabetes Center, Boston, MA 02215, USA
6Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA 02115 USA
Aviv Regev
4Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
7Howard Hughes Medical Institute, Koch Institute of Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA
Joshua Z. Levin
3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge MA 02142, USA
4Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Lee L. Rubin
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
2Harvard Stem Cell Institute, Cambridge, MA 02138, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge MA 02142, USA
Posted January 28, 2022.
Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types
Methodios Ximerakis, Kristina M. Holton, Richard M. Giadone, Ceren Ozek, Monika Saxena, Samara Santiago, Xian Adiconis, Danielle Dionne, Lan Nguyen, Kavya M. Shah, Jill M. Goldstein, Caterina Gasperini, Scott L. Lipnick, Sean K. Simmons, Sean M. Buchanan, Amy J. Wagers, Aviv Regev, Joshua Z. Levin, Lee L. Rubin
bioRxiv 2022.01.27.477911; doi: https://doi.org/10.1101/2022.01.27.477911
Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types
Methodios Ximerakis, Kristina M. Holton, Richard M. Giadone, Ceren Ozek, Monika Saxena, Samara Santiago, Xian Adiconis, Danielle Dionne, Lan Nguyen, Kavya M. Shah, Jill M. Goldstein, Caterina Gasperini, Scott L. Lipnick, Sean K. Simmons, Sean M. Buchanan, Amy J. Wagers, Aviv Regev, Joshua Z. Levin, Lee L. Rubin
bioRxiv 2022.01.27.477911; doi: https://doi.org/10.1101/2022.01.27.477911
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