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Multiple Synaptic Contacts combined with Dendritic Filtering enhance Spatio-Temporal Pattern Recognition capabilities of Single Neurons

View ORCID ProfileDavid Beniaguev, Sapir Shapira, View ORCID ProfileIdan Segev, View ORCID ProfileMichael London
doi: https://doi.org/10.1101/2022.01.28.478132
David Beniaguev
1The Edmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of Jerusalem, Israel
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  • For correspondence: david.beniaguev@gmail.com
Sapir Shapira
1The Edmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of Jerusalem, Israel
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Idan Segev
1The Edmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of Jerusalem, Israel
2Department of Neurobiology, The Hebrew University of Jerusalem, Israel
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Michael London
1The Edmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of Jerusalem, Israel
2Department of Neurobiology, The Hebrew University of Jerusalem, Israel
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Abstract

A cortical neuron typically makes multiple synaptic contacts on the dendrites of a post-synaptic target neuron. The functional implications of this apparent redundancy are unclear. The dendritic location of a synaptic contact affects the time-course of the somatic post-synaptic potential (PSP) due to dendritic cable filtering. Consequently, a single pre-synaptic axonal spike results with a PSP composed of multiple temporal profiles. Here, we developed a “filter-and-fire” (F&F) neuron model that captures these features and show that the memory capacity of this neuron is threefold larger than that of a leaky integrate-and-fire (I&F) neuron, when trained to emit precisely timed output spikes for specific input patterns. Furthermore, the F&F neuron can learn to recognize spatio-temporal input patterns, e.g., MNIST digits, where the I&F model completely fails. Multiple synaptic contacts between pairs of cortical neurons are therefore an important feature rather than a bug and can serve to reduce axonal wiring requirements.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Updated Author List on bioRxiv (in the manuscript itself everything was OK in the first place)

  • https://github.com/SelfishGene/filter_and_fire_neuron

  • https://www.kaggle.com/selfishgene/fiter-and-fire-paper

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted January 28, 2022.
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Multiple Synaptic Contacts combined with Dendritic Filtering enhance Spatio-Temporal Pattern Recognition capabilities of Single Neurons
David Beniaguev, Sapir Shapira, Idan Segev, Michael London
bioRxiv 2022.01.28.478132; doi: https://doi.org/10.1101/2022.01.28.478132
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Multiple Synaptic Contacts combined with Dendritic Filtering enhance Spatio-Temporal Pattern Recognition capabilities of Single Neurons
David Beniaguev, Sapir Shapira, Idan Segev, Michael London
bioRxiv 2022.01.28.478132; doi: https://doi.org/10.1101/2022.01.28.478132

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