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Using the Dynamic Forward Scattering Signal for Optical Coherence Tomography based Blood Flow Quantification

View ORCID ProfileAhhyun Stephanie Nam, Boy Braaf, View ORCID ProfileBenjamin J. Vakoc
doi: https://doi.org/10.1101/2022.02.01.478558
Ahhyun Stephanie Nam
Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114
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  • For correspondence: snam@alum.mit.edu
Boy Braaf
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Benjamin J. Vakoc
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ABSTRACT

To our knowledge, all existing optical coherence tomography approaches for quantifying blood flow, whether Doppler-based or decorrelation-based, analyze light that is back-scattered by moving red blood cells (RBCs). This work investigates the potential advantages of basing these measurements on light that is forward-scattered by RBCs, i.e., by looking at the signals back-scattered from below the vessel. We show experimentally that this results in a flowmetry measure that is insensitive to vessel orientation for vessels that are approximately orthogonal to the imaging beam. We further provide proof-of-principle demonstrations that DFS can be used to measure flow in human retinal and choroidal vessels.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • snam{at}mgh.harvard.edu bvakoc{at}mgh.harvard.edu

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted February 04, 2022.
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Using the Dynamic Forward Scattering Signal for Optical Coherence Tomography based Blood Flow Quantification
Ahhyun Stephanie Nam, Boy Braaf, Benjamin J. Vakoc
bioRxiv 2022.02.01.478558; doi: https://doi.org/10.1101/2022.02.01.478558
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Using the Dynamic Forward Scattering Signal for Optical Coherence Tomography based Blood Flow Quantification
Ahhyun Stephanie Nam, Boy Braaf, Benjamin J. Vakoc
bioRxiv 2022.02.01.478558; doi: https://doi.org/10.1101/2022.02.01.478558

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