Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Reinstating olfactory bulb derived limbic gamma oscillations alleviates depression

View ORCID ProfileQun Li, Yuichi Takeuchi, Jiale Wang, Livia Barcsai, Lizeth K Pedraza, Gábor Kozák, Shinya Nakai, Shigeki Kato, Kazuto Kobayashi, Masahiro Ohsawa, Magor L Lőrincz, Orrin Devinsky, Gyorgy Buzsaki, Antal Berényi
doi: https://doi.org/10.1101/2022.02.01.478683
Qun Li
1MTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged; Szeged, 6720, Hungary
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Qun Li
Yuichi Takeuchi
1MTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged; Szeged, 6720, Hungary
2Department of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University; Nagoya, 467-8603, Japan
3Department of Physiology, Osaka City University Graduate School of Medicine; Osaka, 545-8585, Japan
4Department of Biopharmaceutical Sciences and Pharmacy, Faculty of Pharmaceutical Sciences, Hokkaido University; Sapporo, 060-0812, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jiale Wang
1MTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged; Szeged, 6720, Hungary
5Faculty of Pharmacy, University of Szeged; Szeged, 6720, Hungary
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Livia Barcsai
1MTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged; Szeged, 6720, Hungary
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lizeth K Pedraza
1MTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged; Szeged, 6720, Hungary
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gábor Kozák
1MTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged; Szeged, 6720, Hungary
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shinya Nakai
2Department of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University; Nagoya, 467-8603, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shigeki Kato
6Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine; Fukushima, 960-1295, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kazuto Kobayashi
6Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine; Fukushima, 960-1295, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Masahiro Ohsawa
1MTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged; Szeged, 6720, Hungary
2Department of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University; Nagoya, 467-8603, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Magor L Lőrincz
1MTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged; Szeged, 6720, Hungary
7Department of Physiology, Anatomy and Neuroscience, Faculty of Sciences University of Szeged; Szeged, 6726, Hungary
8Neuroscience Division, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Orrin Devinsky
9Department of Neurology, NYU Langone Comprehensive Epilepsy Center, NYU Grossman School of Medicine, New York, New York
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gyorgy Buzsaki
10Neuroscience Institute, New York University; New York, NY 10016, USA
11Center for Neural Science, New York University, New York, NY 10016, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Antal Berényi
1MTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged; Szeged, 6720, Hungary
11Center for Neural Science, New York University, New York, NY 10016, USA
12HCEMM-SZTE Magnetotherapeutics Research Group, University of Szeged; Szeged, 6720, Hungary
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: drberenyi@gmail.com
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

Although the etiology of major depressive disorder remains poorly understood, impairment of gamma oscillations recently emerged as a potential biomarker for major depression. The olfactory bulb (OB) is a major source of brain wide gamma oscillations and bulbectomy is an animal model for depression. Here we demonstrate that chemogenetic suppression of OB neuronal activity or temporally suppressing the OB to pyriform cortex synaptic transmission decreased gamma oscillation power in multiple brain areas associated with depression-like behaviors. To assess the hypothesized link between depression and diffuse depression of gamma oscillations, we employed gamma phase-dependent closed loop neuromodulation of cortical areas, paced by the native OB output. This procedure alleviated depressive-like behaviors in animals and suggests that restoring gamma oscillations may improve depression in humans.

One Sentence Summary Role of limbic gamma oscillations in depression

Competing Interest Statement

A.B. is the owner of Amplipex Llc. Szeged, Hungary a manufacturer of signal-multiplexed neuronal amplifiers. A.B is a shareholder, chairman and CEO, O.D. is the CMO and Director, GB is a shareholder of Neunos Inc, a Boston, MA company, developing neurostimulator devices.

Footnotes

  • Corrected the author's name

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted February 07, 2022.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Reinstating olfactory bulb derived limbic gamma oscillations alleviates depression
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Reinstating olfactory bulb derived limbic gamma oscillations alleviates depression
Qun Li, Yuichi Takeuchi, Jiale Wang, Livia Barcsai, Lizeth K Pedraza, Gábor Kozák, Shinya Nakai, Shigeki Kato, Kazuto Kobayashi, Masahiro Ohsawa, Magor L Lőrincz, Orrin Devinsky, Gyorgy Buzsaki, Antal Berényi
bioRxiv 2022.02.01.478683; doi: https://doi.org/10.1101/2022.02.01.478683
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Reinstating olfactory bulb derived limbic gamma oscillations alleviates depression
Qun Li, Yuichi Takeuchi, Jiale Wang, Livia Barcsai, Lizeth K Pedraza, Gábor Kozák, Shinya Nakai, Shigeki Kato, Kazuto Kobayashi, Masahiro Ohsawa, Magor L Lőrincz, Orrin Devinsky, Gyorgy Buzsaki, Antal Berényi
bioRxiv 2022.02.01.478683; doi: https://doi.org/10.1101/2022.02.01.478683

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (3609)
  • Biochemistry (7590)
  • Bioengineering (5533)
  • Bioinformatics (20833)
  • Biophysics (10347)
  • Cancer Biology (7998)
  • Cell Biology (11663)
  • Clinical Trials (138)
  • Developmental Biology (6619)
  • Ecology (10227)
  • Epidemiology (2065)
  • Evolutionary Biology (13647)
  • Genetics (9557)
  • Genomics (12859)
  • Immunology (7931)
  • Microbiology (19575)
  • Molecular Biology (7678)
  • Neuroscience (42192)
  • Paleontology (309)
  • Pathology (1259)
  • Pharmacology and Toxicology (2208)
  • Physiology (3272)
  • Plant Biology (7064)
  • Scientific Communication and Education (1295)
  • Synthetic Biology (1953)
  • Systems Biology (5434)
  • Zoology (1119)