Cryomilling Tethered Chromatin Conformation Capture reveal new insights into inter-chromosomal interactions

Jiang Xu; Sanjeev Kumar; Nan Hua; Yi Kou; Xiao Lei; Michael P. Rout; John D. Aitchison; Frank Alber; Lin Chen

doi:10.1101/2022.02.03.478915

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Cryomilling Tethered Chromatin Conformation Capture reveal new insights into inter-chromosomal interactions

View ORCID ProfileJiang Xu, Sanjeev Kumar, Nan Hua, Yi Kou, Xiao Lei, View ORCID ProfileMichael P. Rout, John D. Aitchison, Frank Alber, Lin Chen

doi: https://doi.org/10.1101/2022.02.03.478915

Jiang Xu

1Molecular and Computational Biology, Department of Biological Sciences and Chemistry, University of Southern California, Los Angeles, CA 90089, USA

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Sanjeev Kumar

3Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington 98109, USA

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Nan Hua

2Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA 90095, USA

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Yi Kou

1Molecular and Computational Biology, Department of Biological Sciences and Chemistry, University of Southern California, Los Angeles, CA 90089, USA

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Xiao Lei

1Molecular and Computational Biology, Department of Biological Sciences and Chemistry, University of Southern California, Los Angeles, CA 90089, USA

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Michael P. Rout

5Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, New York 10065, USA

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John D. Aitchison

3Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington 98109, USA

4Departments of Pediatrics and Biochemistry, University of Washington, Seattle, Washington 98195, USA

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Frank Alber

2Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA 90095, USA

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Lin Chen

1Molecular and Computational Biology, Department of Biological Sciences and Chemistry, University of Southern California, Los Angeles, CA 90089, USA

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For correspondence: linchen@usc.edu

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Posted February 12, 2022.

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Cryomilling Tethered Chromatin Conformation Capture reveal new insights into inter-chromosomal interactions

Jiang Xu, Sanjeev Kumar, Nan Hua, Yi Kou, Xiao Lei, Michael P. Rout, John D. Aitchison, Frank Alber, Lin Chen

bioRxiv 2022.02.03.478915; doi: https://doi.org/10.1101/2022.02.03.478915

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Cryomilling Tethered Chromatin Conformation Capture reveal new insights into inter-chromosomal interactions

Jiang Xu, Sanjeev Kumar, Nan Hua, Yi Kou, Xiao Lei, Michael P. Rout, John D. Aitchison, Frank Alber, Lin Chen

bioRxiv 2022.02.03.478915; doi: https://doi.org/10.1101/2022.02.03.478915

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