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Defensive and offensive behaviors in social interaction settings in a Kleefstra syndrome mouse model

Alejandra Alonso, Anumita Samanta, Jacqueline van der Meij, Liz van den Brand, Moritz Negwer, Irene Navarro Lobato, Lisa Genzel
doi: https://doi.org/10.1101/2022.02.03.478985
Alejandra Alonso
1Department of Neuroinformatics, Faculty of Science, Donders Institute for Brain, Cognition and Behaviour, Radboud University, P.O. Box 9010, 6500 GL Nijmegen, The Netherlands
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  • For correspondence: ale.alonsogarrido@donders.ru.nl Lisa.genzel@donders.ru.nl
Anumita Samanta
1Department of Neuroinformatics, Faculty of Science, Donders Institute for Brain, Cognition and Behaviour, Radboud University, P.O. Box 9010, 6500 GL Nijmegen, The Netherlands
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Jacqueline van der Meij
1Department of Neuroinformatics, Faculty of Science, Donders Institute for Brain, Cognition and Behaviour, Radboud University, P.O. Box 9010, 6500 GL Nijmegen, The Netherlands
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Liz van den Brand
1Department of Neuroinformatics, Faculty of Science, Donders Institute for Brain, Cognition and Behaviour, Radboud University, P.O. Box 9010, 6500 GL Nijmegen, The Netherlands
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Moritz Negwer
2Donders Institute for Brain, Cognition and Behaviour, RadboudUMC
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Irene Navarro Lobato
1Department of Neuroinformatics, Faculty of Science, Donders Institute for Brain, Cognition and Behaviour, Radboud University, P.O. Box 9010, 6500 GL Nijmegen, The Netherlands
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Lisa Genzel
1Department of Neuroinformatics, Faculty of Science, Donders Institute for Brain, Cognition and Behaviour, Radboud University, P.O. Box 9010, 6500 GL Nijmegen, The Netherlands
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  • For correspondence: ale.alonsogarrido@donders.ru.nl Lisa.genzel@donders.ru.nl
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Abstract

Kleefstra syndrome in humans is characterized by general delay in development, intellectual disability and autistic features. The mouse model of this disease (Ehmt1+/-) expresses anxiety, autistic-like traits, and aberrant social interactions with non-cagemates. To investigate how Ehmt1+/- mice behave with unfamiliar conspecifics, we allowed adult, male animals to freely interact for 10 minutes in a neutral, novel environment within a host-visitor setting. In 17 out of 74 trials there were defensive and offensive behaviors. Our key finding was that Ehmt1+/- mice displayed defensive postures, attacking and biting; in contrast, wild-type (WT) interacting with other WT did not enact such behaviors. Further, if there was a fight between an Ehmt1+/- and a WT mouse, it was always the Ehmt1+/- who initiated these behaviors.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted February 06, 2022.
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Defensive and offensive behaviors in social interaction settings in a Kleefstra syndrome mouse model
Alejandra Alonso, Anumita Samanta, Jacqueline van der Meij, Liz van den Brand, Moritz Negwer, Irene Navarro Lobato, Lisa Genzel
bioRxiv 2022.02.03.478985; doi: https://doi.org/10.1101/2022.02.03.478985
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Defensive and offensive behaviors in social interaction settings in a Kleefstra syndrome mouse model
Alejandra Alonso, Anumita Samanta, Jacqueline van der Meij, Liz van den Brand, Moritz Negwer, Irene Navarro Lobato, Lisa Genzel
bioRxiv 2022.02.03.478985; doi: https://doi.org/10.1101/2022.02.03.478985

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