New Results
The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters
Lisa Miorin, Chad E. Mire, Shahin Ranjbar, Adam J. Hume, Jessie Huang, View ORCID ProfileNicholas A. Crossland, Kris M White, Manon Laporte, Thomas Kehrer, Viraga Haridas, Elena Moreno, Aya Nambu, Sonia Jangra, Anastasija Cupic, View ORCID ProfileMarion Dejosez, Kristine A. Abo, Anna E. Tseng, Rhiannon B. Werder, Raveen Rathnasinghe, Tinaye Mutetwa, Irene Ramos, Julio Sainz de Aja, Carolina Garcia de Alba Rivas, Michael Schotsaert, Ronald B. Corley, James V. Falvo, Ana Fernandez-Sesma, Carla Kim, Jean-François Rossignol, Andrew A. Wilson, Thomas Zwaka, Darrell N. Kotton, Elke Mühlberger, Adolfo García-Sastre, Anne E. Goldfeld
doi: https://doi.org/10.1101/2022.02.08.479634
Lisa Miorin
1Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
2Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Chad E. Mire
3University of Texas Medical Branch, Galveston, TX, USA
Shahin Ranjbar
4Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA
Adam J. Hume
5National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA
6Department of Microbiology, Boston University School of Medicine, Boston, MA, USA
Jessie Huang
7Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, USA
8The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA, USA
Nicholas A. Crossland
5National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA
9Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA
Kris M White
1Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
2Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Manon Laporte
1Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
2Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Thomas Kehrer
1Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
2Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Viraga Haridas
4Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA
Elena Moreno
1Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
2Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Aya Nambu
4Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA
Sonia Jangra
1Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
2Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Anastasija Cupic
1Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
2Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Marion Dejosez
10Cell, Developmental & Regenerative Biology, Icahn School of Medicine at Mount Sinai; New York, NY, USA
Kristine A. Abo
7Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, USA
8The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA, USA
Anna E. Tseng
5National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA
9Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA
Rhiannon B. Werder
7Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, USA
8The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA, USA
Raveen Rathnasinghe
1Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
2Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Tinaye Mutetwa
1Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Irene Ramos
1Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Julio Sainz de Aja
11Stem Cell Program, Boston Children’s Hospital, Boston, MA, USA
Carolina Garcia de Alba Rivas
11Stem Cell Program, Boston Children’s Hospital, Boston, MA, USA
Michael Schotsaert
1Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
2Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Ronald B. Corley
5National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA
9Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA
James V. Falvo
4Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA
Ana Fernandez-Sesma
1Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Carla Kim
11Stem Cell Program, Boston Children’s Hospital, Boston, MA, USA
12Harvard Stem Cell Institute, Cambridge, Massachusetts
13Department of Genetics, Harvard Medical School, Boston, MA, USA
Jean-François Rossignol
14Romark Institute for Medical Research, Tampa, FL, USA
Andrew A. Wilson
7Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, USA
8The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA, USA
Thomas Zwaka
10Cell, Developmental & Regenerative Biology, Icahn School of Medicine at Mount Sinai; New York, NY, USA
Darrell N. Kotton
7Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, USA
8The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA, USA
9Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA
Elke Mühlberger
5National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA
6Department of Microbiology, Boston University School of Medicine, Boston, MA, USA
Adolfo García-Sastre
1Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
2Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
15Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA
16Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
17Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Anne E. Goldfeld
4Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA
18Division of Infectious Diseases, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
19Department of Immunology and Infectious Diseases, Harvard T.C. Chan School of Public Health, Boston, MA, USA
Posted February 09, 2022.
The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters
Lisa Miorin, Chad E. Mire, Shahin Ranjbar, Adam J. Hume, Jessie Huang, Nicholas A. Crossland, Kris M White, Manon Laporte, Thomas Kehrer, Viraga Haridas, Elena Moreno, Aya Nambu, Sonia Jangra, Anastasija Cupic, Marion Dejosez, Kristine A. Abo, Anna E. Tseng, Rhiannon B. Werder, Raveen Rathnasinghe, Tinaye Mutetwa, Irene Ramos, Julio Sainz de Aja, Carolina Garcia de Alba Rivas, Michael Schotsaert, Ronald B. Corley, James V. Falvo, Ana Fernandez-Sesma, Carla Kim, Jean-François Rossignol, Andrew A. Wilson, Thomas Zwaka, Darrell N. Kotton, Elke Mühlberger, Adolfo García-Sastre, Anne E. Goldfeld
bioRxiv 2022.02.08.479634; doi: https://doi.org/10.1101/2022.02.08.479634
The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters
Lisa Miorin, Chad E. Mire, Shahin Ranjbar, Adam J. Hume, Jessie Huang, Nicholas A. Crossland, Kris M White, Manon Laporte, Thomas Kehrer, Viraga Haridas, Elena Moreno, Aya Nambu, Sonia Jangra, Anastasija Cupic, Marion Dejosez, Kristine A. Abo, Anna E. Tseng, Rhiannon B. Werder, Raveen Rathnasinghe, Tinaye Mutetwa, Irene Ramos, Julio Sainz de Aja, Carolina Garcia de Alba Rivas, Michael Schotsaert, Ronald B. Corley, James V. Falvo, Ana Fernandez-Sesma, Carla Kim, Jean-François Rossignol, Andrew A. Wilson, Thomas Zwaka, Darrell N. Kotton, Elke Mühlberger, Adolfo García-Sastre, Anne E. Goldfeld
bioRxiv 2022.02.08.479634; doi: https://doi.org/10.1101/2022.02.08.479634
Subject Area
Subject Areas
- Biochemistry (11718)
- Bioengineering (8724)
- Bioinformatics (29132)
- Biophysics (14936)
- Cancer Biology (12051)
- Cell Biology (17360)
- Clinical Trials (138)
- Developmental Biology (9406)
- Ecology (14146)
- Epidemiology (2067)
- Evolutionary Biology (18269)
- Genetics (12223)
- Genomics (16768)
- Immunology (11844)
- Microbiology (28016)
- Molecular Biology (11560)
- Neuroscience (60822)
- Paleontology (450)
- Pathology (1864)
- Pharmacology and Toxicology (3231)
- Physiology (4940)
- Plant Biology (10401)
- Synthetic Biology (2878)
- Systems Biology (7333)
- Zoology (1642)