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Seeing the future: a better way to model and test for adaptive developmental plasticity

View ORCID ProfileAnup Malani, View ORCID ProfileStacy Rosenbaum, View ORCID ProfileSusan C. Alberts, View ORCID ProfileElizabeth A. Archie
doi: https://doi.org/10.1101/2022.02.10.479998
Anup Malani
1University of Chicago Law School and National Bureau of Economic Research
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Stacy Rosenbaum
2University of Michigan Department of Anthropology
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  • For correspondence: rosenbas@umich.edu
Susan C. Alberts
3Duke University Departments of Biology and Evolutionary Anthropology
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Elizabeth A. Archie
4University of Notre Dame Department of Biological Sciences
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Abstract

Early life conditions can have profound effects on individual health, longevity, and biological fitness. Two classes of hypotheses are used to explain the evolutionary origins of these effects: developmental constraints (DC) hypotheses, which focus on the deleterious effects of low-quality early-life environments, and predictive adaptive response (PAR) models, which focus on organisms’ predictions about their adult environment, phenotypic adaptations based on that prediction, and the deleterious consequences of incorrect predictions. Despite their popularity, these ideas remain poorly defined. To remedy this, we provide mathematical definitions for DC, PARs, and related concepts, and develop statistical tests derived from these definitions. We use simulations to demonstrate that PARs are more readily detected by tests based on quadratic regressions than by tests based on more commonly used interaction regression models. Specifically, quadratic regression-based tests on simulated data yield 90.7% sensitivity and 71.5% specificity in detecting PARs, while interaction-based tests yield sensitivity and specificity roughly equal to chance. We demonstrate that the poor performance of interaction models stems from two problems: first, they are mathematically incapable of detecting a central prediction of PAR, and second, they conceptually conflate PARs with DC. Our results emphasize the value of formal statistical modeling to reveal the theoretical underpinnings of verbal and visual models, and their importance for helping resolve conflicting and ambiguous results in this field of research. We conclude by providing recommendations for how researchers can make use of explicit definitions and properly-aligned visualizations and statistical tests to make progress in this important research area.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • https://github.com/anup-malani/PAR/blob/d3d9588af6bb96c49f0550c94aa756e6a1261a9f/PAR_simulation_220117b.do

  • 1 Although DC typically focuses on external developmental environments, the hypothesis could theoretically be extended to internal states, mirroring the distinction that is drawn between external and internal PARs. However, we will focus on DC application to external environments.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted February 11, 2022.
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Seeing the future: a better way to model and test for adaptive developmental plasticity
Anup Malani, Stacy Rosenbaum, Susan C. Alberts, Elizabeth A. Archie
bioRxiv 2022.02.10.479998; doi: https://doi.org/10.1101/2022.02.10.479998
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Seeing the future: a better way to model and test for adaptive developmental plasticity
Anup Malani, Stacy Rosenbaum, Susan C. Alberts, Elizabeth A. Archie
bioRxiv 2022.02.10.479998; doi: https://doi.org/10.1101/2022.02.10.479998

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