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Next-generation intranasal Covid-19 vaccine: a polymersome-based protein subunit formulation that provides robust protection against multiple variants of concern and early reduction in viral load of the upper airway in the golden Syrian hamster model

Jian Hang Lam, Devendra Shivhare, Teck Wan Chia, Suet Li Chew, Gaurav Sinsinbar, Ting Yan Aw, Siamy Wong, Shrinivas Venkatraman, Francesca Wei Inng Lim, Pierre Vandepapeliere, Madhavan Nallani
doi: https://doi.org/10.1101/2022.02.12.480188
Jian Hang Lam
1ACM Biolabs Pte Ltd, Singapore
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Devendra Shivhare
1ACM Biolabs Pte Ltd, Singapore
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Teck Wan Chia
1ACM Biolabs Pte Ltd, Singapore
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Suet Li Chew
1ACM Biolabs Pte Ltd, Singapore
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Gaurav Sinsinbar
1ACM Biolabs Pte Ltd, Singapore
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Ting Yan Aw
1ACM Biolabs Pte Ltd, Singapore
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Siamy Wong
1ACM Biolabs Pte Ltd, Singapore
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Shrinivas Venkatraman
1ACM Biolabs Pte Ltd, Singapore
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Francesca Wei Inng Lim
3Singapore General Hospital, Singapore
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Pierre Vandepapeliere
2ACM Biosciences AG, Basel, Switzerland
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  • For correspondence: pvandepapeliere@acmbiosciences.com
Madhavan Nallani
1ACM Biolabs Pte Ltd, Singapore
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  • For correspondence: mnallani@acmbiolabs.com
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Article Information

doi 
https://doi.org/10.1101/2022.02.12.480188
History 
  • February 14, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Jian Hang Lam1,
  2. Devendra Shivhare1,
  3. Teck Wan Chia1,
  4. Suet Li Chew1,
  5. Gaurav Sinsinbar1,
  6. Ting Yan Aw1,
  7. Siamy Wong1,
  8. Shrinivas Venkatraman1,
  9. Francesca Wei Inng Lim3,
  10. Pierre Vandepapeliere2,# and
  11. Madhavan Nallani1,*
  1. 1ACM Biolabs Pte Ltd, Singapore
  2. 2ACM Biosciences AG, Basel, Switzerland
  3. 3Singapore General Hospital, Singapore
  1. ↵* Corresponding author: mnallani{at}acmbiolabs.com; +65 62655646
  2. ↵#Co-corresponding author: pvandepapeliere{at}acmbiosciences.com
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Posted February 14, 2022.
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Next-generation intranasal Covid-19 vaccine: a polymersome-based protein subunit formulation that provides robust protection against multiple variants of concern and early reduction in viral load of the upper airway in the golden Syrian hamster model
Jian Hang Lam, Devendra Shivhare, Teck Wan Chia, Suet Li Chew, Gaurav Sinsinbar, Ting Yan Aw, Siamy Wong, Shrinivas Venkatraman, Francesca Wei Inng Lim, Pierre Vandepapeliere, Madhavan Nallani
bioRxiv 2022.02.12.480188; doi: https://doi.org/10.1101/2022.02.12.480188
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Next-generation intranasal Covid-19 vaccine: a polymersome-based protein subunit formulation that provides robust protection against multiple variants of concern and early reduction in viral load of the upper airway in the golden Syrian hamster model
Jian Hang Lam, Devendra Shivhare, Teck Wan Chia, Suet Li Chew, Gaurav Sinsinbar, Ting Yan Aw, Siamy Wong, Shrinivas Venkatraman, Francesca Wei Inng Lim, Pierre Vandepapeliere, Madhavan Nallani
bioRxiv 2022.02.12.480188; doi: https://doi.org/10.1101/2022.02.12.480188

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