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Experimental infection of mink with SARS-COV-2 Omicron (BA.1) variant leads to symptomatic disease with lung pathology and transmission

Jenni Virtanen, Kirsi Aaltonen, Kristel Kegler, Vinaya Venkat, Thanakorn Niamsap, Lauri Kareinen, Rasmus Malmgren, Olga Kivelä, Nina Atanasova, Pamela Österlund, Teemu Smura, Antti Sukura, Tomas Strandin, Lara Dutra, Olli Vapalahti, Heli Nordgren, Ravi Kant, Tarja Sironen
doi: https://doi.org/10.1101/2022.02.16.480524
Jenni Virtanen
2University of Helsinki, Helsinki, Finland
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  • For correspondence: jenni.me.virtanen@helsinki.fi
Kirsi Aaltonen
2University of Helsinki, Helsinki, Finland
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Kristel Kegler
2University of Helsinki, Helsinki, Finland
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Vinaya Venkat
2University of Helsinki, Helsinki, Finland
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Thanakorn Niamsap
2University of Helsinki, Helsinki, Finland
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Lauri Kareinen
2University of Helsinki, Helsinki, Finland
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Rasmus Malmgren
2University of Helsinki, Helsinki, Finland
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Olga Kivelä
2University of Helsinki, Helsinki, Finland
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Nina Atanasova
2University of Helsinki, Helsinki, Finland
3Finnish Meteorological Institute, Helsinki
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Pamela Österlund
4Finnish Institute for Health and Welfare, Helsinki
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Teemu Smura
2University of Helsinki, Helsinki, Finland
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Antti Sukura
2University of Helsinki, Helsinki, Finland
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Tomas Strandin
2University of Helsinki, Helsinki, Finland
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Lara Dutra
2University of Helsinki, Helsinki, Finland
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Olli Vapalahti
2University of Helsinki, Helsinki, Finland
5Helsinki University Hospital, Helsinki
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Heli Nordgren
2University of Helsinki, Helsinki, Finland
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Ravi Kant
2University of Helsinki, Helsinki, Finland
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Tarja Sironen
2University of Helsinki, Helsinki, Finland
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Abstract

We report an experimental infection of American mink with SARS-CoV-2 Omicron variant and show that minks remain virus RNA positive for days, develop clinical signs and histopathological changes, and transmit the virus to uninfected recipients warranting further studies and preparedness.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted February 16, 2022.
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Experimental infection of mink with SARS-COV-2 Omicron (BA.1) variant leads to symptomatic disease with lung pathology and transmission
Jenni Virtanen, Kirsi Aaltonen, Kristel Kegler, Vinaya Venkat, Thanakorn Niamsap, Lauri Kareinen, Rasmus Malmgren, Olga Kivelä, Nina Atanasova, Pamela Österlund, Teemu Smura, Antti Sukura, Tomas Strandin, Lara Dutra, Olli Vapalahti, Heli Nordgren, Ravi Kant, Tarja Sironen
bioRxiv 2022.02.16.480524; doi: https://doi.org/10.1101/2022.02.16.480524
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Experimental infection of mink with SARS-COV-2 Omicron (BA.1) variant leads to symptomatic disease with lung pathology and transmission
Jenni Virtanen, Kirsi Aaltonen, Kristel Kegler, Vinaya Venkat, Thanakorn Niamsap, Lauri Kareinen, Rasmus Malmgren, Olga Kivelä, Nina Atanasova, Pamela Österlund, Teemu Smura, Antti Sukura, Tomas Strandin, Lara Dutra, Olli Vapalahti, Heli Nordgren, Ravi Kant, Tarja Sironen
bioRxiv 2022.02.16.480524; doi: https://doi.org/10.1101/2022.02.16.480524

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