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Transkingdom mechanism of MAMP generation by chitotriosidase (CHIT1) feeds oligomeric chitin from fungal pathogens and allergens into TLR2-mediated innate immune sensing
View ORCID ProfileTzu-Hsuan Chang, Yamel Cardona Gloria, Margareta J. Hellmann, Carsten Leo Greve, Didier Le Roy, View ORCID ProfileThierry Roger, Lydia Kasper, View ORCID ProfileBernhard Hube, View ORCID ProfileStefan Pusch, View ORCID ProfileNeil Gow, Morten Sørlie, Anne Tøndervik, View ORCID ProfileBruno M. Moerschbacher, View ORCID ProfileAlexander N.R. Weber
doi: https://doi.org/10.1101/2022.02.17.479713
Tzu-Hsuan Chang
aInterfaculty Institute for Cell Biology, Department of Immunology, and Proteome Center Tübingen, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany
Yamel Cardona Gloria
aInterfaculty Institute for Cell Biology, Department of Immunology, and Proteome Center Tübingen, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany
Margareta J. Hellmann
bInstitute for Biology and Biotechnology of Plants, University of Münster, Schlossplatz 8, 48143 Münster, Germany
Carsten Leo Greve
aInterfaculty Institute for Cell Biology, Department of Immunology, and Proteome Center Tübingen, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany
Didier Le Roy
cInfectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
Thierry Roger
cInfectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
Lydia Kasper
dDepartment of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany
Bernhard Hube
dDepartment of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany
eInstitute of Microbiology, Friedrich Schiller University, Jena, Germany
Stefan Pusch
fDepartment of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg and German Cancer Consortium (DKTK), Clinical Cooperation Unit (CCU) Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Neil Gow
gDepartment of Biosciences, Geoffrey Pope Building. Medical Research Council Centre for Medical Mycology at The University of Exeter, University of Exeter, Exeter EX4 4QD, United Kingdom
Morten Sørlie
hDepartment of Chemistry, Biotechnology, and Food Science, Norwegian University of Life Sciences PB 5003 Chr. M. Falsensvei 1, N-1432 Ås, Norway
Anne Tøndervik
iDepartment of Biotechnology and Nanomedicine, SINTEF Industry, Richard Birkelands vei 3B, N-7034 Trondheim, Norway
Bruno M. Moerschbacher
bInstitute for Biology and Biotechnology of Plants, University of Münster, Schlossplatz 8, 48143 Münster, Germany
Alexander N.R. Weber
aInterfaculty Institute for Cell Biology, Department of Immunology, and Proteome Center Tübingen, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany
jiFIT – Cluster of Excellence (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, University of Tübingen, Germany
kCMFI – Cluster of Excellence (EXC 2124) “Controlling Microbes to Fight Infection”, University of Tübingen, Germany
lDeutsches Konsortium für Translationale Krebsforschung (DKTK; German Cancer Consortium), Partner Site Tübingen, Department of Immunology, University of Tübingen, Tübingen, Germany
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Posted February 19, 2022.
Transkingdom mechanism of MAMP generation by chitotriosidase (CHIT1) feeds oligomeric chitin from fungal pathogens and allergens into TLR2-mediated innate immune sensing
Tzu-Hsuan Chang, Yamel Cardona Gloria, Margareta J. Hellmann, Carsten Leo Greve, Didier Le Roy, Thierry Roger, Lydia Kasper, Bernhard Hube, Stefan Pusch, Neil Gow, Morten Sørlie, Anne Tøndervik, Bruno M. Moerschbacher, Alexander N.R. Weber
bioRxiv 2022.02.17.479713; doi: https://doi.org/10.1101/2022.02.17.479713
Transkingdom mechanism of MAMP generation by chitotriosidase (CHIT1) feeds oligomeric chitin from fungal pathogens and allergens into TLR2-mediated innate immune sensing
Tzu-Hsuan Chang, Yamel Cardona Gloria, Margareta J. Hellmann, Carsten Leo Greve, Didier Le Roy, Thierry Roger, Lydia Kasper, Bernhard Hube, Stefan Pusch, Neil Gow, Morten Sørlie, Anne Tøndervik, Bruno M. Moerschbacher, Alexander N.R. Weber
bioRxiv 2022.02.17.479713; doi: https://doi.org/10.1101/2022.02.17.479713
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