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Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance
View ORCID ProfileFabian Fröhlich, View ORCID ProfileLuca Gerosa, View ORCID ProfileJeremy Muhlich, View ORCID ProfilePeter K. Sorger
doi: https://doi.org/10.1101/2022.02.17.480899
Fabian Fröhlich
1Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Luca Gerosa
1Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
2Genentech, Inc., South San Francisco, CA 94080
Jeremy Muhlich
1Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Peter K. Sorger
1Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Posted February 18, 2022.
Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance
Fabian Fröhlich, Luca Gerosa, Jeremy Muhlich, Peter K. Sorger
bioRxiv 2022.02.17.480899; doi: https://doi.org/10.1101/2022.02.17.480899
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