Abstract
Studying proteins through the lens of evolution can reveal conserved features, lineage-specific variants, and their potential functions. MolEvolvR (https://jravilab.org/molevolvr) is a novel web-app enabling researchers to visualize the molecular evolution of their proteins of interest in a phylogenetic context across the tree of life, spanning all superkingdoms. The web-app accepts multiple input formats – protein/domain sequences, homologous proteins, or domain scans – and, using a general-purpose computational workflow, returns detailed homolog data and dynamic graphical summaries (e.g., phylogenetic trees, multiple sequence alignments, domain architectures, domain proximity networks, phyletic spreads, co-occurrence patterns across lineages). Thus, MolEvolvR is a powerful, easy-to-use web interface for computational protein characterization.
Competing Interest Statement
The authors have declared no competing interest.
Footnotes
Updated both front-end (UI) and back-end. Dockerized back-end. Moved the server from MSU to CU Anschutz. Added more help docs, FAQ, run logs, and email support. Updated text and screenshots to match the current web-app. Updated contributions and author list.
