New Results
Reactive astrocytes transduce blood-brain barrier dysfunction through a TNFα-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin
Hyosung Kim, Kun Leng, Jinhee Park, Alexander G. Sorets, Suil Kim, Alena Shostak, Sarah M. Sturgeon, Emma H. Neal, Douglas G. McMahon, View ORCID ProfileMatthew S. Schrag, View ORCID ProfileMartin Kampmann, Ethan S. Lippmann
doi: https://doi.org/10.1101/2022.02.21.481336
Hyosung Kim
1Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA
Kun Leng
2Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA, USA
3Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA
4Medical Scientist Training Program, University of California San Francisco, San Francisco, CA, USA
Jinhee Park
5Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA
Alexander G. Sorets
6Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA
Suil Kim
7Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA
Alena Shostak
8Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA
Sarah M. Sturgeon
1Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA
Emma H. Neal
1Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA
Douglas G. McMahon
7Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA
9Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA
Matthew S. Schrag
7Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA
8Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA
10Vanderbilt Memory and Alzheimer’s Center, Vanderbilt University Medical Center, Nashville, TN, USA
Martin Kampmann
2Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA, USA
11Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA
12Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA
13Chan Zuckerberg Biohub, San Francisco, CA, USA
Ethan S. Lippmann
1Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA
6Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA
7Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA
8Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA
10Vanderbilt Memory and Alzheimer’s Center, Vanderbilt University Medical Center, Nashville, TN, USA

Article usage
Posted February 22, 2022.
Reactive astrocytes transduce blood-brain barrier dysfunction through a TNFα-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin
Hyosung Kim, Kun Leng, Jinhee Park, Alexander G. Sorets, Suil Kim, Alena Shostak, Sarah M. Sturgeon, Emma H. Neal, Douglas G. McMahon, Matthew S. Schrag, Martin Kampmann, Ethan S. Lippmann
bioRxiv 2022.02.21.481336; doi: https://doi.org/10.1101/2022.02.21.481336
Reactive astrocytes transduce blood-brain barrier dysfunction through a TNFα-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin
Hyosung Kim, Kun Leng, Jinhee Park, Alexander G. Sorets, Suil Kim, Alena Shostak, Sarah M. Sturgeon, Emma H. Neal, Douglas G. McMahon, Matthew S. Schrag, Martin Kampmann, Ethan S. Lippmann
bioRxiv 2022.02.21.481336; doi: https://doi.org/10.1101/2022.02.21.481336
Subject Area
Subject Areas
- Biochemistry (13864)
- Bioengineering (10567)
- Bioinformatics (33580)
- Biophysics (17308)
- Cancer Biology (14374)
- Cell Biology (20352)
- Clinical Trials (138)
- Developmental Biology (10969)
- Ecology (16198)
- Epidemiology (2067)
- Evolutionary Biology (20508)
- Genetics (13509)
- Genomics (18801)
- Immunology (13932)
- Microbiology (32465)
- Molecular Biology (13523)
- Neuroscience (70791)
- Paleontology (532)
- Pathology (2222)
- Pharmacology and Toxicology (3778)
- Physiology (5957)
- Plant Biology (12145)
- Synthetic Biology (3401)
- Systems Biology (8234)
- Zoology (1868)