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The structure of insulin granule core determines secretory capacity being reduced in type-2 diabetes

Mohammad Barghouth, Xiaoping Jiang, Mototsugu Nagao, Ning Chen, Daowei Yang, Yingying Ye, Cheng Luan, Maria F. Gomez, View ORCID ProfileAnna M. Blom, Claes B Wollheim, View ORCID ProfileLena Eliasson, Erik Renström, View ORCID ProfileEnming Zhang
doi: https://doi.org/10.1101/2022.02.22.481455
Mohammad Barghouth
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
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Xiaoping Jiang
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
2School of Physical Science & Technology, Southwest University, Chongqing, China
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Mototsugu Nagao
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
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Ning Chen
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
3Department of Endocrinology, Zhongshan Hospital, Fudan University (Xiamen branch), Xiamen, China
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Daowei Yang
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
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Yingying Ye
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
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Cheng Luan
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
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Maria F. Gomez
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
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Anna M. Blom
4Department of Translational Medicine, Lund University, Malmö, Sweden
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  • ORCID record for Anna M. Blom
Claes B Wollheim
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
5Department of Cell Physiology and Metabolism, University Medical Centre, 1 rue Michel-Servet, 1211 Geneva 4, Switzerland
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Lena Eliasson
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
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  • ORCID record for Lena Eliasson
Erik Renström
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
6NanoLund, Lund University, Box 118, 22100 Lund, Sweden
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  • For correspondence: erik.renstrom@med.lu.se enming.zhang@med.lu.se
Enming Zhang
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
6NanoLund, Lund University, Box 118, 22100 Lund, Sweden
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  • ORCID record for Enming Zhang
  • For correspondence: erik.renstrom@med.lu.se enming.zhang@med.lu.se
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Article Information

doi 
https://doi.org/10.1101/2022.02.22.481455
History 
  • February 23, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

  1. Mohammad Barghouth1,
  2. Xiaoping Jiang1,2,
  3. Mototsugu Nagao1,
  4. Ning Chen1,3,
  5. Daowei Yang1,
  6. Yingying Ye1,
  7. Cheng Luan1,
  8. Maria F. Gomez1,
  9. Anna M. Blom4,
  10. Claes B Wollheim1,5,
  11. Lena Eliasson1,
  12. Erik Renström1,6,* and
  13. Enming Zhang1,6,*
  1. 1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
  2. 2School of Physical Science & Technology, Southwest University, Chongqing, China
  3. 3Department of Endocrinology, Zhongshan Hospital, Fudan University (Xiamen branch), Xiamen, China
  4. 4Department of Translational Medicine, Lund University, Malmö, Sweden
  5. 5Department of Cell Physiology and Metabolism, University Medical Centre, 1 rue Michel-Servet, 1211 Geneva 4, Switzerland
  6. 6NanoLund, Lund University, Box 118, 22100 Lund, Sweden
  1. ↵*Correspondence should be addressed to E.R. (erik.renstrom{at}med.lu.se) or E.Z. (enming.zhang{at}med.lu.se)
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Posted February 23, 2022.
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The structure of insulin granule core determines secretory capacity being reduced in type-2 diabetes
Mohammad Barghouth, Xiaoping Jiang, Mototsugu Nagao, Ning Chen, Daowei Yang, Yingying Ye, Cheng Luan, Maria F. Gomez, Anna M. Blom, Claes B Wollheim, Lena Eliasson, Erik Renström, Enming Zhang
bioRxiv 2022.02.22.481455; doi: https://doi.org/10.1101/2022.02.22.481455
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The structure of insulin granule core determines secretory capacity being reduced in type-2 diabetes
Mohammad Barghouth, Xiaoping Jiang, Mototsugu Nagao, Ning Chen, Daowei Yang, Yingying Ye, Cheng Luan, Maria F. Gomez, Anna M. Blom, Claes B Wollheim, Lena Eliasson, Erik Renström, Enming Zhang
bioRxiv 2022.02.22.481455; doi: https://doi.org/10.1101/2022.02.22.481455

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