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The structure of insulin granule core determines secretory capacity being reduced in type-2 diabetes

Mohammad Barghouth, Xiaoping Jiang, Mototsugu Nagao, Ning Chen, Daowei Yang, Yingying Ye, Cheng Luan, Maria F. Gomez, View ORCID ProfileAnna M. Blom, Claes B Wollheim, View ORCID ProfileLena Eliasson, Erik Renström, View ORCID ProfileEnming Zhang
doi: https://doi.org/10.1101/2022.02.22.481455
Mohammad Barghouth
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
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Xiaoping Jiang
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
2School of Physical Science & Technology, Southwest University, Chongqing, China
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Mototsugu Nagao
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
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Ning Chen
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
3Department of Endocrinology, Zhongshan Hospital, Fudan University (Xiamen branch), Xiamen, China
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Daowei Yang
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
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Yingying Ye
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
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Cheng Luan
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
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Maria F. Gomez
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
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Anna M. Blom
4Department of Translational Medicine, Lund University, Malmö, Sweden
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  • ORCID record for Anna M. Blom
Claes B Wollheim
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
5Department of Cell Physiology and Metabolism, University Medical Centre, 1 rue Michel-Servet, 1211 Geneva 4, Switzerland
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Lena Eliasson
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
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  • ORCID record for Lena Eliasson
Erik Renström
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
6NanoLund, Lund University, Box 118, 22100 Lund, Sweden
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  • For correspondence: erik.renstrom@med.lu.se enming.zhang@med.lu.se
Enming Zhang
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
6NanoLund, Lund University, Box 118, 22100 Lund, Sweden
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  • ORCID record for Enming Zhang
  • For correspondence: erik.renstrom@med.lu.se enming.zhang@med.lu.se
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Posted February 23, 2022.
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The structure of insulin granule core determines secretory capacity being reduced in type-2 diabetes
Mohammad Barghouth, Xiaoping Jiang, Mototsugu Nagao, Ning Chen, Daowei Yang, Yingying Ye, Cheng Luan, Maria F. Gomez, Anna M. Blom, Claes B Wollheim, Lena Eliasson, Erik Renström, Enming Zhang
bioRxiv 2022.02.22.481455; doi: https://doi.org/10.1101/2022.02.22.481455
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The structure of insulin granule core determines secretory capacity being reduced in type-2 diabetes
Mohammad Barghouth, Xiaoping Jiang, Mototsugu Nagao, Ning Chen, Daowei Yang, Yingying Ye, Cheng Luan, Maria F. Gomez, Anna M. Blom, Claes B Wollheim, Lena Eliasson, Erik Renström, Enming Zhang
bioRxiv 2022.02.22.481455; doi: https://doi.org/10.1101/2022.02.22.481455

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