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The structure of insulin granule core determines secretory capacity being reduced in type-2 diabetes
Mohammad Barghouth, Xiaoping Jiang, Mototsugu Nagao, Ning Chen, Daowei Yang, Yingying Ye, Cheng Luan, Maria F. Gomez, View ORCID ProfileAnna M. Blom, Claes B Wollheim, View ORCID ProfileLena Eliasson, Erik Renström, View ORCID ProfileEnming Zhang
doi: https://doi.org/10.1101/2022.02.22.481455
Mohammad Barghouth
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
Xiaoping Jiang
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
2School of Physical Science & Technology, Southwest University, Chongqing, China
Mototsugu Nagao
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
Ning Chen
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
3Department of Endocrinology, Zhongshan Hospital, Fudan University (Xiamen branch), Xiamen, China
Daowei Yang
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
Yingying Ye
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
Cheng Luan
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
Maria F. Gomez
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
Anna M. Blom
4Department of Translational Medicine, Lund University, Malmö, Sweden
Claes B Wollheim
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
5Department of Cell Physiology and Metabolism, University Medical Centre, 1 rue Michel-Servet, 1211 Geneva 4, Switzerland
Lena Eliasson
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
Erik Renström
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
6NanoLund, Lund University, Box 118, 22100 Lund, Sweden
Enming Zhang
1Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden
6NanoLund, Lund University, Box 118, 22100 Lund, Sweden

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Posted February 23, 2022.
The structure of insulin granule core determines secretory capacity being reduced in type-2 diabetes
Mohammad Barghouth, Xiaoping Jiang, Mototsugu Nagao, Ning Chen, Daowei Yang, Yingying Ye, Cheng Luan, Maria F. Gomez, Anna M. Blom, Claes B Wollheim, Lena Eliasson, Erik Renström, Enming Zhang
bioRxiv 2022.02.22.481455; doi: https://doi.org/10.1101/2022.02.22.481455
The structure of insulin granule core determines secretory capacity being reduced in type-2 diabetes
Mohammad Barghouth, Xiaoping Jiang, Mototsugu Nagao, Ning Chen, Daowei Yang, Yingying Ye, Cheng Luan, Maria F. Gomez, Anna M. Blom, Claes B Wollheim, Lena Eliasson, Erik Renström, Enming Zhang
bioRxiv 2022.02.22.481455; doi: https://doi.org/10.1101/2022.02.22.481455
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