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Ivermectin does not protect against SARS-CoV-2 infection in the Syrian hamster model

Caroline S. Foo, View ORCID ProfileRana Abdelnabi, Laura Vangeel, Steven De Jonghe, View ORCID ProfileDirk Jochamns, Birgit Weynand, Johan Neyts
doi: https://doi.org/10.1101/2022.02.22.481472
Caroline S. Foo
1KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium
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Rana Abdelnabi
1KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium
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  • ORCID record for Rana Abdelnabi
Laura Vangeel
1KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium
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Steven De Jonghe
1KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium
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Dirk Jochamns
1KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium
2Global Virus Network, GVN
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Birgit Weynand
3KU Leuven Department of Imaging and Pathology, Translational Cell and Tissue Research, B-3000 Leuven, Belgium; Division of Translational Cell and Tissue Research
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Johan Neyts
1KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium
2Global Virus Network, GVN
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  • For correspondence: johan.neyts@kuleuven.be
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Abstract

Ivermectin, an FDA-approved antiparasitic drug, has been reported to have in vitro activity against SARS-CoV-2. An increasing off-label use of Ivermectin for COVID-19 has been reported. We here assessed the effect of Ivermectin in Syrian hamsters infected with the SARS-CoV-2 Beta (B.1.351) variant. Infected animals received a clinically relevant dose of Ivermectin (0.4 mg/kg subcutaneously dosed) once daily for four consecutive days after which the effect was quantified. Ivermectin monotherapy did not reduce lung viral load and even significantly worsened the SARS-CoV-2-induced lung pathology. Additionally, it did not potentiate the activity of Molnupiravir (Lagevrio™) when combined with this drug. This study contributes to the growing body of evidence that Ivermectin does not result in a beneficial effect in the treatment of COVID-19. These findings are important given the increasing, dangerous off-label use of Ivermectin for the treatment of COVID-19.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted February 24, 2022.
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Ivermectin does not protect against SARS-CoV-2 infection in the Syrian hamster model
Caroline S. Foo, Rana Abdelnabi, Laura Vangeel, Steven De Jonghe, Dirk Jochamns, Birgit Weynand, Johan Neyts
bioRxiv 2022.02.22.481472; doi: https://doi.org/10.1101/2022.02.22.481472
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Ivermectin does not protect against SARS-CoV-2 infection in the Syrian hamster model
Caroline S. Foo, Rana Abdelnabi, Laura Vangeel, Steven De Jonghe, Dirk Jochamns, Birgit Weynand, Johan Neyts
bioRxiv 2022.02.22.481472; doi: https://doi.org/10.1101/2022.02.22.481472

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