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Sensory-motor computations in a cortico-pontine pathway

View ORCID ProfileTimothy R. Darlington, View ORCID ProfileStephen G. Lisberger
doi: https://doi.org/10.1101/2022.02.22.481514
Timothy R. Darlington
Department of Neurobiology, Duke University School of Medicine, Durham, NC
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  • For correspondence: timothy.r.darlington@gmail.com
Stephen G. Lisberger
Department of Neurobiology, Duke University School of Medicine, Durham, NC
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Summary

Subcortical circuits decode the output from multiple cortical areas to create commands for movement. By recording during monkeys’ smooth pursuit eye movements, we reveal how the dorsolateral pontine nucleus (DLPN) and nucleus reticularis tegmenti pontis (NRTP) decode cortical output. Preparatory activity is inherited from the smooth eye movement region of the frontal eye fields (FEFSEM). Consistent with its effects on eye movement responses to visual motion, preparatory activity modulates the gain of pontine responses to visual motion input from visual area MT. Furthermore, the “place” code for target speed in area MT becomes the motor command’s “rate” code in the pons, through linear weighting of MT’s output. The division into decoding that happens in the pons and residual computations that occur downstream reveals that the pons is neither a relay nor the source of a final motor command. It is part of a complex, distributed cortical decoder for motor control.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • The authors declare no competing financial interests.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted February 23, 2022.
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Sensory-motor computations in a cortico-pontine pathway
Timothy R. Darlington, Stephen G. Lisberger
bioRxiv 2022.02.22.481514; doi: https://doi.org/10.1101/2022.02.22.481514
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Sensory-motor computations in a cortico-pontine pathway
Timothy R. Darlington, Stephen G. Lisberger
bioRxiv 2022.02.22.481514; doi: https://doi.org/10.1101/2022.02.22.481514

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