Stable iPSC-derived NKX2-1+ Lung Bud Tip Progenitor Organoids Give Rise to Airway and Alveolar Cell Types

Renee F.C. Hein; Ansley S. Conchola; Alexis Fine; Zhiwei Xiao; Tristan Frum; Charlie J. Childs; Yu-Hwai Tsai; Emily M. Holloway; Sha Huang; John Mahoney; Jason R. Spence

doi:10.1101/2022.02.25.481981

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Stable iPSC-derived NKX2-1⁺ Lung Bud Tip Progenitor Organoids Give Rise to Airway and Alveolar Cell Types

View ORCID ProfileRenee F.C. Hein, View ORCID ProfileAnsley S. Conchola, Alexis Fine, Zhiwei Xiao, View ORCID ProfileTristan Frum, View ORCID ProfileCharlie J. Childs, Yu-Hwai Tsai, Emily M. Holloway, Sha Huang, View ORCID ProfileJohn Mahoney, View ORCID ProfileJason R. Spence

doi: https://doi.org/10.1101/2022.02.25.481981

Renee F.C. Hein

1Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI

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Ansley S. Conchola

2Program in Cell and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI

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Alexis Fine

3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI

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Zhiwei Xiao

3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI

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Tristan Frum

3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI

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Charlie J. Childs

1Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI

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Yu-Hwai Tsai

3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI

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Emily M. Holloway

1Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI

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Sha Huang

3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI

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John Mahoney

5Therapeutics Lab, Cystic Fibrosis Foundation, Lexington, MA

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Jason R. Spence

1Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI

2Program in Cell and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI

3Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI

4Department of Biomedical Engineering Medicine, University of Michigan Medical School, Ann Arbor, MI

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For correspondence: spencejr@umich.edu

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Posted February 25, 2022.

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Stable iPSC-derived NKX2-1⁺ Lung Bud Tip Progenitor Organoids Give Rise to Airway and Alveolar Cell Types

Renee F.C. Hein, Ansley S. Conchola, Alexis Fine, Zhiwei Xiao, Tristan Frum, Charlie J. Childs, Yu-Hwai Tsai, Emily M. Holloway, Sha Huang, John Mahoney, Jason R. Spence

bioRxiv 2022.02.25.481981; doi: https://doi.org/10.1101/2022.02.25.481981

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Stable iPSC-derived NKX2-1⁺ Lung Bud Tip Progenitor Organoids Give Rise to Airway and Alveolar Cell Types

Renee F.C. Hein, Ansley S. Conchola, Alexis Fine, Zhiwei Xiao, Tristan Frum, Charlie J. Childs, Yu-Hwai Tsai, Emily M. Holloway, Sha Huang, John Mahoney, Jason R. Spence

bioRxiv 2022.02.25.481981; doi: https://doi.org/10.1101/2022.02.25.481981

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