RK-33, a small molecule inhibitor of host RNA helicase DDX3, suppresses multiple variants of SARS-CoV-2

Farhad Vesuna; Ivan Akhrymuk; Amy Smith; Paul T. Winnard; Shih-Chao Lin; Robert Scharpf; Kylene Kehn-Hall; Venu Raman

doi:10.1101/2022.02.28.482334

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RK-33, a small molecule inhibitor of host RNA helicase DDX3, suppresses multiple variants of SARS-CoV-2

Farhad Vesuna, Ivan Akhrymuk, Amy Smith, Paul T. Winnard Jr., Shih-Chao Lin, Robert Scharpf, Kylene Kehn-Hall, Venu Raman

doi: https://doi.org/10.1101/2022.02.28.482334

Farhad Vesuna

1Division of Cancer Imaging Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD

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Ivan Akhrymuk

2Department of Biomedical Science and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA

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Amy Smith

2Department of Biomedical Science and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA

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Paul T. Winnard Jr.

1Division of Cancer Imaging Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD

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Shih-Chao Lin

3Bachelor Degree Program in Marine Biotechnology, College of Life Sciences, National Taiwan Ocean University, Keelung, Taiwan

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Robert Scharpf

4Division of Biostatistics and Bioinformatics, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD

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Kylene Kehn-Hall

2Department of Biomedical Science and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA

5Center for Zoonotic and Arthropod-borne Pathogens, Virginia Polytechnic Institute and State University, Blacksburg, VA

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For correspondence: kkehnhall@vt.edu vraman2@jhmi.edu

Venu Raman

6Division of Cancer Imaging Research, Department of Radiology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD

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For correspondence: kkehnhall@vt.edu vraman2@jhmi.edu

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RK-33, a small molecule inhibitor of host RNA helicase DDX3, suppresses multiple variants of SARS-CoV-2

Farhad Vesuna, Ivan Akhrymuk, Amy Smith, Paul T. Winnard Jr., Shih-Chao Lin, Robert Scharpf, Kylene Kehn-Hall, Venu Raman

bioRxiv 2022.02.28.482334; doi: https://doi.org/10.1101/2022.02.28.482334

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RK-33, a small molecule inhibitor of host RNA helicase DDX3, suppresses multiple variants of SARS-CoV-2

Farhad Vesuna, Ivan Akhrymuk, Amy Smith, Paul T. Winnard Jr., Shih-Chao Lin, Robert Scharpf, Kylene Kehn-Hall, Venu Raman

bioRxiv 2022.02.28.482334; doi: https://doi.org/10.1101/2022.02.28.482334

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