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An Arrayed Genome-Wide Perturbation Screen Identifies the Ribonucleoprotein hnRNP K As Rate-Limiting for Prion Propagation
View ORCID ProfileMerve Avar, View ORCID ProfileDaniel Heinzer, View ORCID ProfileAlana M. Thackray, Yingjun Liu, View ORCID ProfileMarian Hruska-Plochan, View ORCID ProfileStefano Sellitto, View ORCID ProfileElke Schaper, View ORCID ProfileDaniel P. Pease, View ORCID ProfileJiang-An Yin, View ORCID ProfileAsvin K.K. Lakkaraju, View ORCID ProfileMarc Emmenegger, View ORCID ProfileMarco Losa, View ORCID ProfileAndra Chincisan, View ORCID ProfileSimone Hornemann, Magdalini Polymenidou, View ORCID ProfileRaymond Bujdoso, View ORCID ProfileAdriano Aguzzi
doi: https://doi.org/10.1101/2022.03.03.482765
Merve Avar
1Institute of Neuropathology, University of Zurich, CH-8091Zurich, Switzerland
Daniel Heinzer
1Institute of Neuropathology, University of Zurich, CH-8091Zurich, Switzerland
Alana M. Thackray
2University of Cambridge, Department of Veterinary Medicine, Madingley Road, Cambridge, CB3 OES, UK
Yingjun Liu
1Institute of Neuropathology, University of Zurich, CH-8091Zurich, Switzerland
Marian Hruska-Plochan
3Department of Quantitative Biomedicine, University of Zurich, CH-8057, Switzerland
Stefano Sellitto
1Institute of Neuropathology, University of Zurich, CH-8091Zurich, Switzerland
Elke Schaper
1Institute of Neuropathology, University of Zurich, CH-8091Zurich, Switzerland
Daniel P. Pease
1Institute of Neuropathology, University of Zurich, CH-8091Zurich, Switzerland
Jiang-An Yin
1Institute of Neuropathology, University of Zurich, CH-8091Zurich, Switzerland
Asvin K.K. Lakkaraju
1Institute of Neuropathology, University of Zurich, CH-8091Zurich, Switzerland
Marc Emmenegger
1Institute of Neuropathology, University of Zurich, CH-8091Zurich, Switzerland
Marco Losa
1Institute of Neuropathology, University of Zurich, CH-8091Zurich, Switzerland
Andra Chincisan
1Institute of Neuropathology, University of Zurich, CH-8091Zurich, Switzerland
Simone Hornemann
1Institute of Neuropathology, University of Zurich, CH-8091Zurich, Switzerland
Magdalini Polymenidou
3Department of Quantitative Biomedicine, University of Zurich, CH-8057, Switzerland
Raymond Bujdoso
2University of Cambridge, Department of Veterinary Medicine, Madingley Road, Cambridge, CB3 OES, UK
Adriano Aguzzi
1Institute of Neuropathology, University of Zurich, CH-8091Zurich, Switzerland
Posted March 04, 2022.
An Arrayed Genome-Wide Perturbation Screen Identifies the Ribonucleoprotein hnRNP K As Rate-Limiting for Prion Propagation
Merve Avar, Daniel Heinzer, Alana M. Thackray, Yingjun Liu, Marian Hruska-Plochan, Stefano Sellitto, Elke Schaper, Daniel P. Pease, Jiang-An Yin, Asvin K.K. Lakkaraju, Marc Emmenegger, Marco Losa, Andra Chincisan, Simone Hornemann, Magdalini Polymenidou, Raymond Bujdoso, Adriano Aguzzi
bioRxiv 2022.03.03.482765; doi: https://doi.org/10.1101/2022.03.03.482765
An Arrayed Genome-Wide Perturbation Screen Identifies the Ribonucleoprotein hnRNP K As Rate-Limiting for Prion Propagation
Merve Avar, Daniel Heinzer, Alana M. Thackray, Yingjun Liu, Marian Hruska-Plochan, Stefano Sellitto, Elke Schaper, Daniel P. Pease, Jiang-An Yin, Asvin K.K. Lakkaraju, Marc Emmenegger, Marco Losa, Andra Chincisan, Simone Hornemann, Magdalini Polymenidou, Raymond Bujdoso, Adriano Aguzzi
bioRxiv 2022.03.03.482765; doi: https://doi.org/10.1101/2022.03.03.482765
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