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Soluble P2X7 receptor is elevated in the plasma of COVID-19 patients and correlates with disease severity

Julio García-Villalba, View ORCID ProfileLaura Hurtado-Navarro, View ORCID ProfileAlejandro Peñín-Franch, Cristina Molina-López, View ORCID ProfileLaura Martínez-Alarcón, View ORCID ProfileDiego Angosto-Bazarra, View ORCID ProfileAlberto Baroja-Mazo, View ORCID ProfilePablo Pelegrín
doi: https://doi.org/10.1101/2022.03.04.483019
Julio García-Villalba
1Biomedical Research Institute of Murcia (IMIB-Arrixaca), University Clinical Hospital Virgen Arrixaca, 30120 Murcia, Spain
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Laura Hurtado-Navarro
1Biomedical Research Institute of Murcia (IMIB-Arrixaca), University Clinical Hospital Virgen Arrixaca, 30120 Murcia, Spain
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  • ORCID record for Laura Hurtado-Navarro
Alejandro Peñín-Franch
1Biomedical Research Institute of Murcia (IMIB-Arrixaca), University Clinical Hospital Virgen Arrixaca, 30120 Murcia, Spain
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Cristina Molina-López
1Biomedical Research Institute of Murcia (IMIB-Arrixaca), University Clinical Hospital Virgen Arrixaca, 30120 Murcia, Spain
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Laura Martínez-Alarcón
1Biomedical Research Institute of Murcia (IMIB-Arrixaca), University Clinical Hospital Virgen Arrixaca, 30120 Murcia, Spain
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Diego Angosto-Bazarra
1Biomedical Research Institute of Murcia (IMIB-Arrixaca), University Clinical Hospital Virgen Arrixaca, 30120 Murcia, Spain
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Alberto Baroja-Mazo
1Biomedical Research Institute of Murcia (IMIB-Arrixaca), University Clinical Hospital Virgen Arrixaca, 30120 Murcia, Spain
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Pablo Pelegrín
1Biomedical Research Institute of Murcia (IMIB-Arrixaca), University Clinical Hospital Virgen Arrixaca, 30120 Murcia, Spain
2Department of Biochemistry and Molecular Biology B and Immunology, Faculty of Medicine, University of Murcia, 30120 Murcia, Spain
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  • For correspondence: pablo.pelegrin@imib.es
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Abstract

Inflammation is a tightly coordinated response against bacterial and viral infections, triggered by the production of pro-inflammatory cytokines. SARS-CoV-2 infection induces COVID-19 disease, characterized with an inflammatory response mediated by the activation of the NLRP3 inflammasome resulting with the production of IL-1β and IL-18 together with pyroptotic cell death. Severe inflammation in the lungs of SARS-CoV-2 infected individuals associate with pneumonia, hypoxia and acute respiratory distress syndrome, being the cause of the deaths associated to COVID-19. Here we found that together with the increase of IL-6, IL-18 and the IL-1 receptor antagonist in the plasma of COVID-19 patients, the purinergic P2X7 receptor was also elevated. Increase of COVID-19 disease severity and C-reactive protein concentration positively correlated with increased concentration of the P2X7 receptor in the plasma, but not with IL-18 cytokine. P2X7 receptor was found in the supernatant of human peripheral blood mononuclear cells after inflammasome activation, suggesting that P2X7 receptor determination in the plasma could be a novel biomarker of COVID-19 disease severity.

Competing Interest Statement

LH-N, LM-A, DA-B, AB-M and PP are co-founders of Viva in vitro diagnostics SL, but declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The other authors declare no competing interests.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted March 07, 2022.
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Soluble P2X7 receptor is elevated in the plasma of COVID-19 patients and correlates with disease severity
Julio García-Villalba, Laura Hurtado-Navarro, Alejandro Peñín-Franch, Cristina Molina-López, Laura Martínez-Alarcón, Diego Angosto-Bazarra, Alberto Baroja-Mazo, Pablo Pelegrín
bioRxiv 2022.03.04.483019; doi: https://doi.org/10.1101/2022.03.04.483019
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Soluble P2X7 receptor is elevated in the plasma of COVID-19 patients and correlates with disease severity
Julio García-Villalba, Laura Hurtado-Navarro, Alejandro Peñín-Franch, Cristina Molina-López, Laura Martínez-Alarcón, Diego Angosto-Bazarra, Alberto Baroja-Mazo, Pablo Pelegrín
bioRxiv 2022.03.04.483019; doi: https://doi.org/10.1101/2022.03.04.483019

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