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DiSCERN - Deep Single Cell Expression ReconstructioN for improved cell clustering and cell subtype and state detection

View ORCID ProfileFabian Hausmann, Can Ergen-Behr, Robin Khatri, Mohamed Marouf, Sonja Hänzelmann, Nicola Gagliani, Samuel Huber, Pierre Machart, View ORCID ProfileStefan Bonn
doi: https://doi.org/10.1101/2022.03.09.483600
Fabian Hausmann
aInstitute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
bCenter for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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  • ORCID record for Fabian Hausmann
Can Ergen-Behr
aInstitute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Robin Khatri
aInstitute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
bCenter for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Mohamed Marouf
aInstitute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Sonja Hänzelmann
aInstitute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
bCenter for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
fIII. Department of Medicine, University Medical Center Hamburg-Eppendorf,20246 Hamburg, Germany
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Nicola Gagliani
cSection of Molecular Immunology and Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
dHamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
eDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
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Samuel Huber
cSection of Molecular Immunology and Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
dHamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
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Pierre Machart
aInstitute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
bCenter for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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  • For correspondence: pierre.machart@neclab.eu sbonn@uke.de
Stefan Bonn
aInstitute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
bCenter for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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  • ORCID record for Stefan Bonn
  • For correspondence: pierre.machart@neclab.eu sbonn@uke.de
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Article Information

doi 
https://doi.org/10.1101/2022.03.09.483600
History 
  • June 23, 2022.

Article Versions

  • Version 1 (March 9, 2022 - 12:49).
  • Version 2 (March 10, 2022 - 07:19).
  • Version 3 (April 13, 2022 - 07:14).
  • Version 4 (June 15, 2022 - 08:35).
  • You are viewing Version 5, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Fabian Hausmanna,b,1,
  2. Can Ergen-Behra,1,
  3. Robin Khatria,b,
  4. Mohamed Maroufa,
  5. Sonja Hänzelmanna,b,f,
  6. Nicola Gaglianic,d,e,
  7. Samuel Huberc,d,
  8. Pierre Macharta,b,* and
  9. Stefan Bonna,b,*
  1. aInstitute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  2. bCenter for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  3. cSection of Molecular Immunology and Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
  4. dHamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
  5. eDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
  6. fIII. Department of Medicine, University Medical Center Hamburg-Eppendorf,20246 Hamburg, Germany
  1. ↵*Corresponding authors Email addresses: pierre.machart{at}neclab.eu (Pierre Machart), sbonn{at}uke.de (Stefan Bonn)
  1. ↵1 Authors contributed equally

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Posted June 23, 2022.
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DiSCERN - Deep Single Cell Expression ReconstructioN for improved cell clustering and cell subtype and state detection
Fabian Hausmann, Can Ergen-Behr, Robin Khatri, Mohamed Marouf, Sonja Hänzelmann, Nicola Gagliani, Samuel Huber, Pierre Machart, Stefan Bonn
bioRxiv 2022.03.09.483600; doi: https://doi.org/10.1101/2022.03.09.483600
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DiSCERN - Deep Single Cell Expression ReconstructioN for improved cell clustering and cell subtype and state detection
Fabian Hausmann, Can Ergen-Behr, Robin Khatri, Mohamed Marouf, Sonja Hänzelmann, Nicola Gagliani, Samuel Huber, Pierre Machart, Stefan Bonn
bioRxiv 2022.03.09.483600; doi: https://doi.org/10.1101/2022.03.09.483600

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