Cryo-EM structure of amyloid fibril formed by α-synuclein hereditary A53E mutation

Chuanqi Sun; Kang Zhou; Peter DePaola; Woo Shik Shin; Trae Hillyer; Michael R. Sawaya; Z. Hong Zhou; Lin Jiang

doi:10.1101/2022.03.11.483992

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Cryo-EM structure of amyloid fibril formed by α-synuclein hereditary A53E mutation

Chuanqi Sun, Kang Zhou, Peter DePaola IV, Woo Shik Shin, Trae Hillyer, Michael R. Sawaya, View ORCID ProfileZ. Hong Zhou, Lin Jiang

doi: https://doi.org/10.1101/2022.03.11.483992

Chuanqi Sun

1Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA

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Kang Zhou

2California Nano Systems Institute, UCLA, Los Angeles, CA 90095, USA

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Peter DePaola IV

1Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA

3Departments of Biological Chemistry and Chemistry and Biochemistry, Howard Hughes Medical Institute, UCLA-DOE Institute, UCLA, Los Angeles, CA 90095, USA

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Woo Shik Shin

4Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USA

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Trae Hillyer

4Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USA

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Michael R. Sawaya

3Departments of Biological Chemistry and Chemistry and Biochemistry, Howard Hughes Medical Institute, UCLA-DOE Institute, UCLA, Los Angeles, CA 90095, USA

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Z. Hong Zhou

2California Nano Systems Institute, UCLA, Los Angeles, CA 90095, USA

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ORCID record for Z. Hong Zhou

Lin Jiang

1Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA

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For correspondence: jianglin@ucla.edu

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Cryo-EM structure of amyloid fibril formed by α-synuclein hereditary A53E mutation

Chuanqi Sun, Kang Zhou, Peter DePaola IV, Woo Shik Shin, Trae Hillyer, Michael R. Sawaya, Z. Hong Zhou, Lin Jiang

bioRxiv 2022.03.11.483992; doi: https://doi.org/10.1101/2022.03.11.483992

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Cryo-EM structure of amyloid fibril formed by α-synuclein hereditary A53E mutation

Chuanqi Sun, Kang Zhou, Peter DePaola IV, Woo Shik Shin, Trae Hillyer, Michael R. Sawaya, Z. Hong Zhou, Lin Jiang

bioRxiv 2022.03.11.483992; doi: https://doi.org/10.1101/2022.03.11.483992

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