MHC-I binding affinity derived metrics fail to predict tumor specific neoantigen immunogenicity

Guadalupe Nibeyro; Romina Girotti; Laura Prato; Gabriel Moron; Hugo D. Luján; Elmer A. Fernandez

doi:10.1101/2022.03.14.484285

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MHC-I binding affinity derived metrics fail to predict tumor specific neoantigen immunogenicity

Guadalupe Nibeyro, Romina Girotti, Laura Prato, Gabriel Moron, View ORCID ProfileHugo D. Luján, Elmer A. Fernandez

doi: https://doi.org/10.1101/2022.03.14.484285

Guadalupe Nibeyro

1Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas (CIDIE), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)/Universidad Católica de Córdoba (UCC). X5016HDK. Córdoba, Argentina

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Romina Girotti

2Laboratorio de Inmuno Oncologia Traslacional (Instituto de Biología y Medicina Experimental - IBYME) - CONICET

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Laura Prato

3Instituto Académico Pedagógico de Ciencias Básicas y Aplicadas, Universidad Nacional de Villa María, Villa María, Córdoba X5900, Argentina

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Gabriel Moron

4Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina

5Consejo Nacional de Investigaciones Científicas y Técnicas, Centro de Investigaciones en Bioquímica Clínica e Inmunología, Córdoba, Argentina

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Hugo D. Luján

6Facultad de Ciencias de la Salud, Universidad Católica de Córdoba (UCC). X5016HDK. Córdoba, Argentina

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ORCID record for Hugo D. Luján

Elmer A. Fernandez

7Facultad de Ingeniería. Universidad Católica de Córdoba. X5016HDK. Córdoba, Argentina

8Facultad de Ingeniería, FCEFyN Universidad Nacional de Córdoba (UNC). X5016. Córdoba, Argentina

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For correspondence: efernandez@cidie.ucc.edu.ar

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supplementary material[supplements/484285_file02.pdf]
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Supplementary Table 2[supplements/484285_file04.pdf]
Supplementary Table 3[supplements/484285_file05.pdf]
supplementary table 4[supplements/484285_file06.pdf]

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Posted March 17, 2022.

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MHC-I binding affinity derived metrics fail to predict tumor specific neoantigen immunogenicity

Guadalupe Nibeyro, Romina Girotti, Laura Prato, Gabriel Moron, Hugo D. Luján, Elmer A. Fernandez

bioRxiv 2022.03.14.484285; doi: https://doi.org/10.1101/2022.03.14.484285

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MHC-I binding affinity derived metrics fail to predict tumor specific neoantigen immunogenicity

Guadalupe Nibeyro, Romina Girotti, Laura Prato, Gabriel Moron, Hugo D. Luján, Elmer A. Fernandez

bioRxiv 2022.03.14.484285; doi: https://doi.org/10.1101/2022.03.14.484285

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