Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Robust group- but limited individual-level (longitudinal) reliability and insights into cross-phases response prediction of conditioned fear

View ORCID ProfileMaren Klingelhöfer-Jens, View ORCID ProfileMana R. Ehlers, View ORCID ProfileManuel Kuhn, Vincent Keyaniyan, View ORCID ProfileTina B. Lonsdorf
doi: https://doi.org/10.1101/2022.03.15.484434
Maren Klingelhöfer-Jens
1Institute for Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Maren Klingelhöfer-Jens
  • For correspondence: m.klingelhoefer-jens@uke.de
Mana R. Ehlers
1Institute for Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Mana R. Ehlers
Manuel Kuhn
1Institute for Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
2Department of Psychiatry, Harvard Medical School, and Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Manuel Kuhn
Vincent Keyaniyan
1Institute for Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tina B. Lonsdorf
1Institute for Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Tina B. Lonsdorf
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Data/Code
  • Preview PDF
Loading

Abstract

Here we follow the call to target measurement reliability as a key prerequisite for individual-level predictions in translational neuroscience by investigating i) longitudinal reliability at the individual and ii) group level, iii) cross-sectional reliability and iv) response predictability across experimental phases. 120 individuals performed a fear conditioning paradigm twice six month apart. Analyses of skin conductance responses, fear ratings and BOLD-fMRI with different data transformations and included numbers of trials were conducted. While longitudinal reliability was generally poor to moderate at the individual level, it was good for acquisition but not extinction at the group-level. Cross-sectional reliability was satisfactory. Higher responding in preceding phases predicted higher responding in subsequent experimental phases at a weak to moderate level depending on data specifications. In sum, the results suggest the feasibility of individual-level predictions for (very) short time intervals (e.g., cross-phases) while predictions for longer time intervals may be problematic.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • https://zenodo.org/record/6359920#.YjDKlDUxlhE

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
Back to top
PreviousNext
Posted March 18, 2022.
Download PDF

Supplementary Material

Data/Code
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Robust group- but limited individual-level (longitudinal) reliability and insights into cross-phases response prediction of conditioned fear
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Robust group- but limited individual-level (longitudinal) reliability and insights into cross-phases response prediction of conditioned fear
Maren Klingelhöfer-Jens, Mana R. Ehlers, Manuel Kuhn, Vincent Keyaniyan, Tina B. Lonsdorf
bioRxiv 2022.03.15.484434; doi: https://doi.org/10.1101/2022.03.15.484434
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Robust group- but limited individual-level (longitudinal) reliability and insights into cross-phases response prediction of conditioned fear
Maren Klingelhöfer-Jens, Mana R. Ehlers, Manuel Kuhn, Vincent Keyaniyan, Tina B. Lonsdorf
bioRxiv 2022.03.15.484434; doi: https://doi.org/10.1101/2022.03.15.484434

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (4086)
  • Biochemistry (8761)
  • Bioengineering (6479)
  • Bioinformatics (23340)
  • Biophysics (11750)
  • Cancer Biology (9149)
  • Cell Biology (13247)
  • Clinical Trials (138)
  • Developmental Biology (7416)
  • Ecology (11369)
  • Epidemiology (2066)
  • Evolutionary Biology (15087)
  • Genetics (10398)
  • Genomics (14009)
  • Immunology (9121)
  • Microbiology (22040)
  • Molecular Biology (8779)
  • Neuroscience (47366)
  • Paleontology (350)
  • Pathology (1420)
  • Pharmacology and Toxicology (2482)
  • Physiology (3704)
  • Plant Biology (8050)
  • Scientific Communication and Education (1431)
  • Synthetic Biology (2208)
  • Systems Biology (6016)
  • Zoology (1249)