Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Tuning of motor outputs produced by spinal stimulation during voluntary control of torque directions in monkeys

View ORCID ProfileMiki Kaneshige, Kei Obara, View ORCID ProfileMichiaki Suzuki, Toshiki Tazoe, View ORCID ProfileYukio Nishimura
doi: https://doi.org/10.1101/2022.03.16.484577
Miki Kaneshige
1Neural Prosthetics Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6, Kamikitazawa, Setagaya, 158-8506, Tokyo, Japan
2The Japan Society for the Promotion of Science, 5-3-1 Kojimachi, Chiyoda, 102-0083, Tokyo, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Miki Kaneshige
Kei Obara
1Neural Prosthetics Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6, Kamikitazawa, Setagaya, 158-8506, Tokyo, Japan
3Division of Neural Engineering, Graduate School of Medical and Dental Sciences, Niigata University, 757, Ichibancho, Asahimachi-dori, Chuo, Niigata, 951-8510, Niigata, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michiaki Suzuki
1Neural Prosthetics Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6, Kamikitazawa, Setagaya, 158-8506, Tokyo, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Michiaki Suzuki
Toshiki Tazoe
1Neural Prosthetics Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6, Kamikitazawa, Setagaya, 158-8506, Tokyo, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yukio Nishimura
1Neural Prosthetics Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6, Kamikitazawa, Setagaya, 158-8506, Tokyo, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Yukio Nishimura
  • For correspondence: nishimura-yk@igakuken.or.jp
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Spinal stimulation is a promising method to restore motor function after impairment of descending pathways. While paresis, a weakness of voluntary movements driven by surviving descending pathways, can benefit from spinal stimulation, the effects of descending commands on motor outputs produced by spinal stimulation are unclear. Here, we show that descending commands amplify stimulus-evoked joint torque and the function of intraspinal elements. During the wrist torque tracking task, optimized currents of spinal stimulation over the cervical enlargement facilitated and/or suppressed activities of forelimb muscles. Magnitudes of these effects were dependent on directions of voluntarily-produced torque and positively correlated with levels of voluntary muscle activity. Furthermore, the directions of evoked wrist torque corresponded to the directions of voluntarily-produced torque. These results suggest that spinal stimulation is beneficial in cases of partial lesion of descending pathways by compensating for reduced descending commands through activation of excitatory and inhibitory synaptic connections to motoneurons.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
Back to top
PreviousNext
Posted March 18, 2022.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Tuning of motor outputs produced by spinal stimulation during voluntary control of torque directions in monkeys
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Tuning of motor outputs produced by spinal stimulation during voluntary control of torque directions in monkeys
Miki Kaneshige, Kei Obara, Michiaki Suzuki, Toshiki Tazoe, Yukio Nishimura
bioRxiv 2022.03.16.484577; doi: https://doi.org/10.1101/2022.03.16.484577
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Tuning of motor outputs produced by spinal stimulation during voluntary control of torque directions in monkeys
Miki Kaneshige, Kei Obara, Michiaki Suzuki, Toshiki Tazoe, Yukio Nishimura
bioRxiv 2022.03.16.484577; doi: https://doi.org/10.1101/2022.03.16.484577

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (3686)
  • Biochemistry (7767)
  • Bioengineering (5666)
  • Bioinformatics (21237)
  • Biophysics (10553)
  • Cancer Biology (8159)
  • Cell Biology (11905)
  • Clinical Trials (138)
  • Developmental Biology (6737)
  • Ecology (10388)
  • Epidemiology (2065)
  • Evolutionary Biology (13838)
  • Genetics (9694)
  • Genomics (13054)
  • Immunology (8121)
  • Microbiology (19936)
  • Molecular Biology (7825)
  • Neuroscience (42959)
  • Paleontology (318)
  • Pathology (1276)
  • Pharmacology and Toxicology (2256)
  • Physiology (3350)
  • Plant Biology (7207)
  • Scientific Communication and Education (1309)
  • Synthetic Biology (1998)
  • Systems Biology (5528)
  • Zoology (1126)