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No evidence of induced skin cancer or other skin abnormalities after long term (66 week) chronic exposure to 222-nm far-UVC radiation

David Welch, Norman J. Kleiman, Peter C. Arden, Christine L. Kuryla, Manuela Buonanno, Brian Ponnaiya, Xuefeng Wu, David J. Brenner
doi: https://doi.org/10.1101/2022.03.16.484636
David Welch
1Center for Radiological Research, Columbia University Irving Medical Center, New York, NY
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  • For correspondence: dw2600@cumc.columbia.edu
Norman J. Kleiman
2Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY
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Peter C. Arden
2Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY
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Christine L. Kuryla
2Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY
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Manuela Buonanno
1Center for Radiological Research, Columbia University Irving Medical Center, New York, NY
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Brian Ponnaiya
1Center for Radiological Research, Columbia University Irving Medical Center, New York, NY
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Xuefeng Wu
1Center for Radiological Research, Columbia University Irving Medical Center, New York, NY
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David J. Brenner
1Center for Radiological Research, Columbia University Irving Medical Center, New York, NY
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ABSTRACT

Far-UVC radiation, typically defined as 200-235 nm, has similar or greater anti-microbial efficacy compared to conventional 254-nm germicidal radiation. In addition, biophysical considerations of the interaction of far-UVC with tissue, as well as multiple short-term safety studies in animal models and humans, suggest that far-UVC exposure may be safe for skin and eye tissue. Nevertheless, the potential for skin cancer after chronic long-term exposure to far-UVC has not been studied. Here, we assessed far-UVC induced carcinogenic skin changes and other pathological dermal abnormalities in 96 SKH-1 hairless mice of both sexes that were exposed to average daily dorsal skin doses of 396 mJ/cm2, 126 mJ/cm2 or 56 mJ/cm2 of 222 nm far-UVC radiation for 66 weeks, 5 days per week, 8 hours per day, as well as similarly-treated unexposed controls. No evidence for increased skin cancer, abnormal skin growths, or incidental skin pathology findings was observed in the far-UVC exposed mice. In addition, there were no significant changes in morbidity or mortality. The findings from this study support the long-term safety of long-term chronic exposure to far-UVC radiation, and therefore its potential suitability as a practical anti-microbial approach to reduce airborne viral and bacterial loads in occupied indoor settings.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted March 18, 2022.
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No evidence of induced skin cancer or other skin abnormalities after long term (66 week) chronic exposure to 222-nm far-UVC radiation
David Welch, Norman J. Kleiman, Peter C. Arden, Christine L. Kuryla, Manuela Buonanno, Brian Ponnaiya, Xuefeng Wu, David J. Brenner
bioRxiv 2022.03.16.484636; doi: https://doi.org/10.1101/2022.03.16.484636
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No evidence of induced skin cancer or other skin abnormalities after long term (66 week) chronic exposure to 222-nm far-UVC radiation
David Welch, Norman J. Kleiman, Peter C. Arden, Christine L. Kuryla, Manuela Buonanno, Brian Ponnaiya, Xuefeng Wu, David J. Brenner
bioRxiv 2022.03.16.484636; doi: https://doi.org/10.1101/2022.03.16.484636

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