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High neutralizing antibody levels against SARS-CoV-2 Omicron after UB-612 booster vaccination

View ORCID ProfileFarshad Guirakhoo, View ORCID ProfileShixia Wang, Chang Yi Wang, Hui-Kai Kuo, Wen-Jiun Peng, Hope Liu, Lixia Wang, Marina Johnson, Adam Hunt, Mei Mei Hu, Thomas P Monath, Alexander Rumyantsev, David Goldblatt
doi: https://doi.org/10.1101/2022.03.18.484436
Farshad Guirakhoo
1Vaxxinity Inc; Dallas, TX, USA
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  • For correspondence: farshad@vaxxinity.com
Shixia Wang
1Vaxxinity Inc; Dallas, TX, USA
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Chang Yi Wang
2United Biomedical Inc Asia; Taipei, Taiwan
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Hui-Kai Kuo
2United Biomedical Inc Asia; Taipei, Taiwan
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Wen-Jiun Peng
2United Biomedical Inc Asia; Taipei, Taiwan
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Hope Liu
2United Biomedical Inc Asia; Taipei, Taiwan
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Lixia Wang
1Vaxxinity Inc; Dallas, TX, USA
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Marina Johnson
3Great Ormond Street Institute of Child Health, University College London; London, UK
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Adam Hunt
3Great Ormond Street Institute of Child Health, University College London; London, UK
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Mei Mei Hu
1Vaxxinity Inc; Dallas, TX, USA
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Thomas P Monath
1Vaxxinity Inc; Dallas, TX, USA
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Alexander Rumyantsev
1Vaxxinity Inc; Dallas, TX, USA
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David Goldblatt
3Great Ormond Street Institute of Child Health, University College London; London, UK
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Abstract

Omicron, a highly transmissible SARS-CoV-2, emerged in November 2021. The high mutation rates within spike protein of Omicron raised concerns about increased breakthrough infections among the vaccinated. We tested cross-reactivity of antibodies induced by UB-612 against Omicron and other variants. After 2 doses, UB-612 elicited low levels of neutralization antibodies against ancestral virus and Omicron. A booster dose delivered 7-9 months after primary vaccination dramatically increased antibody levels, with only a 1.4-fold loss in neutralization titer against Omicron compared to the ancestral strain. Using a model bridging vaccine efficacy with ancestral virus RBD binding antibody responses, predicted efficacy against symptomatic COVID-19 after UB-612 booster is estimated at 95%. UB-612 is anticipated to be a potent booster against current and emerging SARS-CoV-2 variants.

One-Sentence Summary UB-612 booster induced broadly neutralizing antibodies against Omicron and is presumed to be protective against COVID-19.

Competing Interest Statement

FG, SW, LW, MMH, TM and AR are employees at Vaxxinity, Inc, Dallas, TX, USA. CYW, WJP, and HL are employees at United Biomedical Inc Asia, Taipei, Taiwan.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted March 21, 2022.
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High neutralizing antibody levels against SARS-CoV-2 Omicron after UB-612 booster vaccination
Farshad Guirakhoo, Shixia Wang, Chang Yi Wang, Hui-Kai Kuo, Wen-Jiun Peng, Hope Liu, Lixia Wang, Marina Johnson, Adam Hunt, Mei Mei Hu, Thomas P Monath, Alexander Rumyantsev, David Goldblatt
bioRxiv 2022.03.18.484436; doi: https://doi.org/10.1101/2022.03.18.484436
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High neutralizing antibody levels against SARS-CoV-2 Omicron after UB-612 booster vaccination
Farshad Guirakhoo, Shixia Wang, Chang Yi Wang, Hui-Kai Kuo, Wen-Jiun Peng, Hope Liu, Lixia Wang, Marina Johnson, Adam Hunt, Mei Mei Hu, Thomas P Monath, Alexander Rumyantsev, David Goldblatt
bioRxiv 2022.03.18.484436; doi: https://doi.org/10.1101/2022.03.18.484436

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