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Multi-omics analyses of MEN1 missense mutations identify disruption of menin-MLL and menin-JunD interactions as critical requirements for molecular pathogenicity
Koen M.A. Dreijerink, Ezgi Ozyerli-Goknar, Stefanie Koidl, Ewoud J. van der Lelij, Priscilla van den Heuvel, Jeffrey J. Kooijman, Martin L. Biniossek, Kees W. Rodenburg, Sheikh Nizamuddin, View ORCID ProfileH.T. Marc Timmers
doi: https://doi.org/10.1101/2022.03.22.485279
Koen M.A. Dreijerink
1Department of Endocrinology, Amsterdam UMC, Amsterdam, The Netherlands
Ezgi Ozyerli-Goknar
2German Cancer Consortium (DKTK) partner site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
3Department of Urology, Medical Center-University of Freiburg, Freiburg, Germany
Stefanie Koidl
2German Cancer Consortium (DKTK) partner site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
3Department of Urology, Medical Center-University of Freiburg, Freiburg, Germany
Ewoud J. van der Lelij
1Department of Endocrinology, Amsterdam UMC, Amsterdam, The Netherlands
Priscilla van den Heuvel
4School of Life Sciences, and Research Group of Technologies of Analyses in Life Sciences (ATLS), Avans University of Applied Sciences, Breda, The Netherlands
Jeffrey J. Kooijman
4School of Life Sciences, and Research Group of Technologies of Analyses in Life Sciences (ATLS), Avans University of Applied Sciences, Breda, The Netherlands
Martin L. Biniossek
5Institute for Molecular Medicine and Cell Research, University of Freiburg, Freiburg, Germany
Kees W. Rodenburg
4School of Life Sciences, and Research Group of Technologies of Analyses in Life Sciences (ATLS), Avans University of Applied Sciences, Breda, The Netherlands
Sheikh Nizamuddin
2German Cancer Consortium (DKTK) partner site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
3Department of Urology, Medical Center-University of Freiburg, Freiburg, Germany
H.T. Marc Timmers
2German Cancer Consortium (DKTK) partner site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
3Department of Urology, Medical Center-University of Freiburg, Freiburg, Germany
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Posted March 22, 2022.
Multi-omics analyses of MEN1 missense mutations identify disruption of menin-MLL and menin-JunD interactions as critical requirements for molecular pathogenicity
Koen M.A. Dreijerink, Ezgi Ozyerli-Goknar, Stefanie Koidl, Ewoud J. van der Lelij, Priscilla van den Heuvel, Jeffrey J. Kooijman, Martin L. Biniossek, Kees W. Rodenburg, Sheikh Nizamuddin, H.T. Marc Timmers
bioRxiv 2022.03.22.485279; doi: https://doi.org/10.1101/2022.03.22.485279
Multi-omics analyses of MEN1 missense mutations identify disruption of menin-MLL and menin-JunD interactions as critical requirements for molecular pathogenicity
Koen M.A. Dreijerink, Ezgi Ozyerli-Goknar, Stefanie Koidl, Ewoud J. van der Lelij, Priscilla van den Heuvel, Jeffrey J. Kooijman, Martin L. Biniossek, Kees W. Rodenburg, Sheikh Nizamuddin, H.T. Marc Timmers
bioRxiv 2022.03.22.485279; doi: https://doi.org/10.1101/2022.03.22.485279
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