Abstract
Retinotopy, like all long-range projections, can arise from the axons themselves or their targets, but details of the connectivity remain unknown. Using two-photon axonal imaging, we functionally mapped the mouse retinocollicular projection at single-cell resolution. We found a near-perfect match between the spatial patterns of retinal ganglion cell axon terminals in the superior colliculus and their corresponding receptive fields, indicating that retinotopy arises from topographic axonal organizations at single-cell precision.
Competing Interest Statement
The authors have declared no competing interest.
Footnotes
Competing interests: The authors declare no competing financial interests.
Acronyms
- 2D
- two-dimensional
- AAV
- adeno-associated virus
- CNMF
- constrained non-negative matrix factorization
- RF
- receptive field
- RGC
- retinal ganglion cells
- SC
- superior colliculus
- SD
- standard deviation
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Posted April 08, 2022.
Topographic projection of retinal ganglion cell axons at single-cell precision underlies retinotopy in the mouse superior colliculus
