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Individual behavioral trajectories shape whole-brain connectivity in mice

Jadna Bogado Lopes, Anna N. Senko, Klaas Bahnsen, Daniel Geisler, Eugene Kim, Michel Bernanos, View ORCID ProfileDiana Cash, Stefan Ehrlich, View ORCID ProfileAnthony C. Vernon, View ORCID ProfileGerd Kempermann
doi: https://doi.org/10.1101/2022.03.25.485806
Jadna Bogado Lopes
1German Center for Neurodegenerative Diseases (DZNE) Dresden; 01307 Dresden, Germany
2Center for Regenerative Therapies Dresden (CRTD), TU Dresden; 01307 Dresden, Germany
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Anna N. Senko
1German Center for Neurodegenerative Diseases (DZNE) Dresden; 01307 Dresden, Germany
2Center for Regenerative Therapies Dresden (CRTD), TU Dresden; 01307 Dresden, Germany
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Klaas Bahnsen
3Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden; 01307, Dresden, Germany
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Daniel Geisler
3Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden; 01307, Dresden, Germany
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Eugene Kim
4Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London; London, UK
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Michel Bernanos
4Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London; London, UK
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Diana Cash
4Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London; London, UK
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Stefan Ehrlich
3Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden; 01307, Dresden, Germany
5Department of Child and Adolescent Psychiatry, Faculty of Medicine, Eating Disorder Treatment and Research Center, TU Dresden; Dresden, Germany
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Anthony C. Vernon
6Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London; London, UK
7MRC Centre for Neurodevelopmental Disorders, King’s College London; London, UK
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  • For correspondence: anthony.vernon@kcl.ac.uk gerd.kempermann@tu-dresden.de
Gerd Kempermann
1German Center for Neurodegenerative Diseases (DZNE) Dresden; 01307 Dresden, Germany
2Center for Regenerative Therapies Dresden (CRTD), TU Dresden; 01307 Dresden, Germany
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  • For correspondence: anthony.vernon@kcl.ac.uk gerd.kempermann@tu-dresden.de
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Abstract

It is widely assumed that our actions shape our brains and that the resulting connections determine who we are. To test this idea in a reductionist setting, in which genes and environment are controlled, we investigated differences in neuroanatomy and structural covariance by ex vivo structural magnetic resonance imaging (MRI) in mice whose behavioral activity was continuously tracked for 3 months in a large, enriched environment. We confirmed that environmental enrichment increases mouse hippocampal volumes. Stratifying the enriched group according to individual longitudinal behavioral trajectories, however, revealed striking differences in mouse brain structural covariance in continuously highly active mice compared to those whose trajectories showed signs of habituating activity. Network-based statistics identified distinct sub-networks of murine structural covariance underlying these differences in behavioral activity. Together, these results reveal that differentiated behavioral trajectories of mice in an enriched environment are associated with differences in brain connectivity.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Competing Interest Statement: The authors declare that they have no competing interests.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted March 26, 2022.
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Individual behavioral trajectories shape whole-brain connectivity in mice
Jadna Bogado Lopes, Anna N. Senko, Klaas Bahnsen, Daniel Geisler, Eugene Kim, Michel Bernanos, Diana Cash, Stefan Ehrlich, Anthony C. Vernon, Gerd Kempermann
bioRxiv 2022.03.25.485806; doi: https://doi.org/10.1101/2022.03.25.485806
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Individual behavioral trajectories shape whole-brain connectivity in mice
Jadna Bogado Lopes, Anna N. Senko, Klaas Bahnsen, Daniel Geisler, Eugene Kim, Michel Bernanos, Diana Cash, Stefan Ehrlich, Anthony C. Vernon, Gerd Kempermann
bioRxiv 2022.03.25.485806; doi: https://doi.org/10.1101/2022.03.25.485806

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