Spatial transcriptomic analysis of childhood ependymoma implicates unresolved wound healing as a driver of tumor progression

Rui Fu; Gregory A. Norris; Nicholas Willard; Andrea M. Griesinger; Kent A. Riemondy; Vladimir Amani; Enrique Grimaldo; Faith Harris; Todd C. Hankinson; Siddhartha Mitra; Timothy A. Ritzmann; Richard R. Grundy; Nicholas K. Foreman; Andrew M. Donson

doi:10.1101/2022.03.29.486280

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Spatial transcriptomic analysis of childhood ependymoma implicates unresolved wound healing as a driver of tumor progression

Rui Fu, Gregory A. Norris, Nicholas Willard, Andrea M. Griesinger, View ORCID ProfileKent A. Riemondy, Vladimir Amani, Enrique Grimaldo, Faith Harris, Todd C. Hankinson, Siddhartha Mitra, Timothy A. Ritzmann, Richard R. Grundy, Nicholas K. Foreman, View ORCID ProfileAndrew M. Donson

doi: https://doi.org/10.1101/2022.03.29.486280

Rui Fu

1RNA Biosciences Initiative, University of Colorado Denver, Aurora, Colorado

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Gregory A. Norris

2Department of Pediatrics, University of Colorado Denver, Aurora, Colorado

3Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children’s Hospital Colorado, Aurora, Colorado

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Nicholas Willard

5Department of Pathology, University of Colorado Denver, Aurora, Colorado

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Andrea M. Griesinger

2Department of Pediatrics, University of Colorado Denver, Aurora, Colorado

3Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children’s Hospital Colorado, Aurora, Colorado

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Kent A. Riemondy

1RNA Biosciences Initiative, University of Colorado Denver, Aurora, Colorado

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ORCID record for Kent A. Riemondy

Vladimir Amani

2Department of Pediatrics, University of Colorado Denver, Aurora, Colorado

3Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children’s Hospital Colorado, Aurora, Colorado

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Enrique Grimaldo

2Department of Pediatrics, University of Colorado Denver, Aurora, Colorado

3Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children’s Hospital Colorado, Aurora, Colorado

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Faith Harris

2Department of Pediatrics, University of Colorado Denver, Aurora, Colorado

3Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children’s Hospital Colorado, Aurora, Colorado

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Todd C. Hankinson

3Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children’s Hospital Colorado, Aurora, Colorado

4Department of Neurosurgery, University of Colorado Denver, Aurora, Colorado

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Siddhartha Mitra

2Department of Pediatrics, University of Colorado Denver, Aurora, Colorado

3Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children’s Hospital Colorado, Aurora, Colorado

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Timothy A. Ritzmann

6Children’s Brain Tumor Research Centre, School of Medicine, University of Nottingham, Nottingham, UK

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Richard R. Grundy

6Children’s Brain Tumor Research Centre, School of Medicine, University of Nottingham, Nottingham, UK

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Nicholas K. Foreman

2Department of Pediatrics, University of Colorado Denver, Aurora, Colorado

3Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children’s Hospital Colorado, Aurora, Colorado

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Andrew M. Donson

2Department of Pediatrics, University of Colorado Denver, Aurora, Colorado

3Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children’s Hospital Colorado, Aurora, Colorado

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ORCID record for Andrew M. Donson
For correspondence: andrew.donson@cuanschutz.edu

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Supplementary Data 2[supplements/486280_file05.xlsx]

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Posted March 29, 2022.

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Spatial transcriptomic analysis of childhood ependymoma implicates unresolved wound healing as a driver of tumor progression

Rui Fu, Gregory A. Norris, Nicholas Willard, Andrea M. Griesinger, Kent A. Riemondy, Vladimir Amani, Enrique Grimaldo, Faith Harris, Todd C. Hankinson, Siddhartha Mitra, Timothy A. Ritzmann, Richard R. Grundy, Nicholas K. Foreman, Andrew M. Donson

bioRxiv 2022.03.29.486280; doi: https://doi.org/10.1101/2022.03.29.486280

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