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Evolution of CRISPR-associated Endonucleases as Inferred from Resurrected Proteins
View ORCID ProfileBorja Alonso-Lerma, View ORCID ProfileYlenia Jabalera, View ORCID ProfileMatias Morin, Almudena Fernandez, View ORCID ProfileSara Samperio, Ane Quesada, View ORCID ProfileAntonio Reifs, Sergio Fernández-Peñalver, Yolanda Benitez, Lucia Soletto, View ORCID ProfileJose A Gavira, Adrian Diaz, View ORCID ProfileWim Vranken, View ORCID ProfileBenjamin P. Kleinstiver, View ORCID ProfileAvencia Sanchez-Mejias, Marc Güell, View ORCID ProfileFrancisco JM Mojica, View ORCID ProfileMiguel A Moreno-Pelayo, View ORCID ProfileLluis Montoliu, View ORCID ProfileRaul Perez-Jimenez
doi: https://doi.org/10.1101/2022.03.30.485982
Borja Alonso-Lerma
1CIC nanoGUNE BRTA, San Sebastian, Spain
Ylenia Jabalera
1CIC nanoGUNE BRTA, San Sebastian, Spain
Matias Morin
2Servicio de Genética, Hospital Universitario Ramón y Cajal, IRYCIS and Centro de Investigaciones Biomédicas en Red de Enfermedades Raras (CIBERER), Madrid, Spain
Almudena Fernandez
3Department of Molecular and Cellular Biology, National Centre for Biotechnology (CNB-CSIC) and Centre for Biomedical Network Research on Rare Diseases (CIBERER-ISCIII), Madrid, Spain
Sara Samperio
1CIC nanoGUNE BRTA, San Sebastian, Spain
Ane Quesada
1CIC nanoGUNE BRTA, San Sebastian, Spain
Antonio Reifs
1CIC nanoGUNE BRTA, San Sebastian, Spain
Sergio Fernández-Peñalver
2Servicio de Genética, Hospital Universitario Ramón y Cajal, IRYCIS and Centro de Investigaciones Biomédicas en Red de Enfermedades Raras (CIBERER), Madrid, Spain
Yolanda Benitez
3Department of Molecular and Cellular Biology, National Centre for Biotechnology (CNB-CSIC) and Centre for Biomedical Network Research on Rare Diseases (CIBERER-ISCIII), Madrid, Spain
4INGEMM, Hospital Universitario La Paz, CIBERER-ISCIII, Madrid, Spain
Lucia Soletto
2Servicio de Genética, Hospital Universitario Ramón y Cajal, IRYCIS and Centro de Investigaciones Biomédicas en Red de Enfermedades Raras (CIBERER), Madrid, Spain
Jose A Gavira
5Laboratorio de Estudios Cristalográficos, IACT (CSIC-UGR), Armilla, Granada, Spain
Adrian Diaz
6Interuniversity Institute of Bioinformatics in Brussels, ULB-VUB, Brussels 1050, Belgium
7Structural Biology Brussels, Vrije Universiteit Brussel, Brussels 1050, Belgium
Wim Vranken
6Interuniversity Institute of Bioinformatics in Brussels, ULB-VUB, Brussels 1050, Belgium
7Structural Biology Brussels, Vrije Universiteit Brussel, Brussels 1050, Belgium
8Structural Biology Research Centre, VIB, Brussels 1050, Belgium
Benjamin P. Kleinstiver
9Center for Genomic Medicine and Department of Pathology, Massachusetts General Hospital, Boston, MA, 02114, USA
10Department of Pathology, Harvard Medical School, Boston, MA, 02115, USA
Avencia Sanchez-Mejias
11Integra Therapeutics S.L., Barcelona, Spain
Marc Güell
11Integra Therapeutics S.L., Barcelona, Spain
12Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain
Francisco JM Mojica
13Dpto. Fisiología, Genética y Microbiología and Instituto Multidisciplinar para el Estudio del Medio “Ramón Margalef”, Universidad de Alicante, Alicante, Spain
Miguel A Moreno-Pelayo
2Servicio de Genética, Hospital Universitario Ramón y Cajal, IRYCIS and Centro de Investigaciones Biomédicas en Red de Enfermedades Raras (CIBERER), Madrid, Spain
Lluis Montoliu
3Department of Molecular and Cellular Biology, National Centre for Biotechnology (CNB-CSIC) and Centre for Biomedical Network Research on Rare Diseases (CIBERER-ISCIII), Madrid, Spain
Raul Perez-Jimenez
1CIC nanoGUNE BRTA, San Sebastian, Spain
14Ikerbasque Foundation for Science, Bilbao, Spain
Article usage
Posted April 01, 2022.
Evolution of CRISPR-associated Endonucleases as Inferred from Resurrected Proteins
Borja Alonso-Lerma, Ylenia Jabalera, Matias Morin, Almudena Fernandez, Sara Samperio, Ane Quesada, Antonio Reifs, Sergio Fernández-Peñalver, Yolanda Benitez, Lucia Soletto, Jose A Gavira, Adrian Diaz, Wim Vranken, Benjamin P. Kleinstiver, Avencia Sanchez-Mejias, Marc Güell, Francisco JM Mojica, Miguel A Moreno-Pelayo, Lluis Montoliu, Raul Perez-Jimenez
bioRxiv 2022.03.30.485982; doi: https://doi.org/10.1101/2022.03.30.485982
Evolution of CRISPR-associated Endonucleases as Inferred from Resurrected Proteins
Borja Alonso-Lerma, Ylenia Jabalera, Matias Morin, Almudena Fernandez, Sara Samperio, Ane Quesada, Antonio Reifs, Sergio Fernández-Peñalver, Yolanda Benitez, Lucia Soletto, Jose A Gavira, Adrian Diaz, Wim Vranken, Benjamin P. Kleinstiver, Avencia Sanchez-Mejias, Marc Güell, Francisco JM Mojica, Miguel A Moreno-Pelayo, Lluis Montoliu, Raul Perez-Jimenez
bioRxiv 2022.03.30.485982; doi: https://doi.org/10.1101/2022.03.30.485982
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