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The mouse claustrum synaptically connects cortical network motifs

Houman Qadir, Brent W. Stewart, Jonathan W. VanRyzin, View ORCID ProfileQiong Wu, Shuo Chen, David A. Seminowicz, View ORCID ProfileBrian N. Mathur
doi: https://doi.org/10.1101/2022.03.31.486634
Houman Qadir
1Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, USA
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Brent W. Stewart
2Department of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA
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Jonathan W. VanRyzin
1Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, USA
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Qiong Wu
3Department of Epidemiology & Public Health, Maryland Psychiatric Research Center, Catonsville, MD, USA
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Shuo Chen
3Department of Epidemiology & Public Health, Maryland Psychiatric Research Center, Catonsville, MD, USA
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David A. Seminowicz
2Department of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA
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Brian N. Mathur
1Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, USA
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  • ORCID record for Brian N. Mathur
  • For correspondence: BMathur@som.umaryland.edu
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Summary

Spatially distant areas of cerebral cortex coordinate their activity into networks that are integral to cognitive processing. A common structural motif of cortical networks is co-activated frontal and posterior cortical regions. Knowledge of the neural circuit mechanisms underlying such widespread inter-areal cortical coordination is lacking. Using anesthetized mouse functional magnetic resonance imaging (fMRI) we discovered that mouse frontal cortical functional connectivity reflects the common cortical network motif in its functional connectivity to posterior cortices, but also demonstrates significant functional connectivity with the claustrum. Exploring whether the claustrum may synaptically support such network architecture, we used a channelrhodopsin-assisted electrophysiological circuit mapping approach to assess the strength of synaptic connectivity of 35 unique frontal cortico-claustral-cortical connections through 1,050 subtype-identified claustrum projection neurons. We observed significant trans-claustral synaptic connectivity from the anterior cingulate cortex and prelimbic prefrontal cortex back to originating frontal cortical regions as well as to posteriorly-lying visual and parietal association cortices contralaterally. The infralimbic prefrontal cortex possessed significant trans-claustral synaptic connectivity with the posteriorly-lying retrosplenial cortex, but to a far lesser degree with visual and parietal association cortices. These data reveal discrete extended cortical pathways through the claustrum that are positioned to support cortical network motifs central to cognitive control functions.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted April 01, 2022.
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The mouse claustrum synaptically connects cortical network motifs
Houman Qadir, Brent W. Stewart, Jonathan W. VanRyzin, Qiong Wu, Shuo Chen, David A. Seminowicz, Brian N. Mathur
bioRxiv 2022.03.31.486634; doi: https://doi.org/10.1101/2022.03.31.486634
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The mouse claustrum synaptically connects cortical network motifs
Houman Qadir, Brent W. Stewart, Jonathan W. VanRyzin, Qiong Wu, Shuo Chen, David A. Seminowicz, Brian N. Mathur
bioRxiv 2022.03.31.486634; doi: https://doi.org/10.1101/2022.03.31.486634

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