Abstract
Current cluster scaled genomics data processing solutions rely on big data frameworks like Apache Spark, Hadoop and HDFS for data scheduling, processing and storage. These frameworks come with additional computation and memory overheads by default. It has been observed that scaling genomics dataset processing beyond 32 nodes is not efficient on such frameworks.
To overcome the inefficiencies of big data frameworks for processing genomics data on clusters, we introduce a low-overhead and highly scalable solution on a SLURM based HPC batch system. This solution uses Apache Arrow as in-memory columnar data format to store genomics data efficiently and Arrow Flight as a network protocol to move and schedule this data across the HPC nodes with low communication overhead.
As a use case, we use NGS short reads DNA sequencing data for pre-processing and variant calling applications. This solution outperforms existing Apache Spark based big data solutions in term of both computation time (2x) and lower communication overhead (more than 20-60% depending on cluster size). Our solution has similar performance to MPI-based HPC solutions, with the added advantage of easy programmability and transparent big data scalability. The whole solution is Python and shell script based, which makes it flexible to update and integrate alternative variant callers. Our solution is publicly available on GitHub at https://github.com/abs-tudelft/time-to-fly-high/genomics.
Competing Interest Statement
The authors have declared no competing interest.
Footnotes
Authors’ addresses: Tanveer Ahmad, Delft University of Technology, Delft, The Netherlands, t.ahmad{at}tudelft.nl; Chengxin Ma, Delft University of Technology, Delft, The Netherlands; Zaid Al-Ars, Delft University of Technology, Delft, The Netherlands, z.al-ars{at}tudelft.nl; H. Peter Hofstee, IBM Systems, Austin, Texas, USA, hofstee{at}us.ibm.com.
https://github.com/abs-tudelft/time-to-fly-high/tree/main/genomics
