Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Unaltered T cell responses to common antigens in individuals with Parkinson’s disease

View ORCID ProfileGregory P. Williams, Kaylin Muskat, April Frazier, View ORCID ProfileYaqian Xu, View ORCID ProfileJosé Mateus, Alba Grifoni, View ORCID ProfileRicardo da Silva Antunes, Daniela Weiskopf, Amy W. Amara, View ORCID ProfileDavid G. Standaert, Jennifer G. Goldman, View ORCID ProfileIrene Litvan, View ORCID ProfileRoy N. Alcalay, View ORCID ProfileDavid Sulzer, View ORCID ProfileCecilia S. Lindestam Arlehamn, Alessandro Sette
doi: https://doi.org/10.1101/2022.04.05.487195
Gregory P. Williams
1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA
2Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Gregory P. Williams
Kaylin Muskat
1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
April Frazier
1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA
2Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yaqian Xu
2Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD
3Department of Psychiatry, Columbia University Irving Medical Center, New York State Psychiatric Institute, New York, NY 10032, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Yaqian Xu
José Mateus
1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for José Mateus
Alba Grifoni
1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ricardo da Silva Antunes
1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Ricardo da Silva Antunes
Daniela Weiskopf
1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Amy W. Amara
2Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD
4Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, 35233, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David G. Standaert
2Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD
4Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, 35233, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for David G. Standaert
Jennifer G. Goldman
5Shirley Ryan AbilityLab, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Irene Litvan
6Department of Neuroscience, University of California San Diego, La Jolla, CA, 92093, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Irene Litvan
Roy N. Alcalay
8Neurological Institute, Tel Aviv Sourasky Medical Center; Tel Aviv, 6423906, Israel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Roy N. Alcalay
David Sulzer
2Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD
3Department of Psychiatry, Columbia University Irving Medical Center, New York State Psychiatric Institute, New York, NY 10032, USA
9Departments of Psychiatry and Pharmacology, Columbia University; New York State Psychiatric Institute, New York, NY 10032, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for David Sulzer
Cecilia S. Lindestam Arlehamn
1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA
2Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Cecilia S. Lindestam Arlehamn
  • For correspondence: alex@lji.org cecilia@lji.org
Alessandro Sette
1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA
2Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD
10Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: alex@lji.org cecilia@lji.org
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

Background and Objectives Parkinson’s disease (PD) is associated with a heightened inflammatory state, including activated T cells. However, it is unclear whether these PD T cell responses are antigen specific or more indicative of generalized hyperresponsiveness. Our objective was to measure and compare antigen-specific T cell responses directed towards antigens derived from commonly encountered human pathogens/vaccines in patients with PD and age-matched healthy controls (HC).

Methods Peripheral blood mononuclear cells (PBMCs) from 20 PD patients and 19 age-matched HCs were screened. Antigen specific T cell responses were measured by flow cytometry using a combination of the activation induced marker (AIM) assay and intracellular cytokine staining.

Results Here we show that both PD patients and HCs show similar T cell activation levels to several antigens derived from commonly encountered human pathogens/vaccines in the general population. Similarly, we also observed no difference between HC and PD in the levels of CD4 and CD8 T cell derived cytokines produced in response to any of the common antigens tested. These antigens encompassed both viral (coronavirus, rhinovirus, respiratory syncytial virus, influenza, cytomegalovirus) and bacterial (pertussis, tetanus) targets.

Conclusions These results suggest the T cell dysfunction observed in PD may not extend itself to abnormal responses to commonly encountered or vaccine-target antigens. Our study supports the notion that the targets of inflammatory T cell responses in PD may be more directed towards autoantigens like α-synuclein (α-syn) rather than common foreign antigens.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
Back to top
PreviousNext
Posted April 08, 2022.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Unaltered T cell responses to common antigens in individuals with Parkinson’s disease
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Unaltered T cell responses to common antigens in individuals with Parkinson’s disease
Gregory P. Williams, Kaylin Muskat, April Frazier, Yaqian Xu, José Mateus, Alba Grifoni, Ricardo da Silva Antunes, Daniela Weiskopf, Amy W. Amara, David G. Standaert, Jennifer G. Goldman, Irene Litvan, Roy N. Alcalay, David Sulzer, Cecilia S. Lindestam Arlehamn, Alessandro Sette
bioRxiv 2022.04.05.487195; doi: https://doi.org/10.1101/2022.04.05.487195
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Unaltered T cell responses to common antigens in individuals with Parkinson’s disease
Gregory P. Williams, Kaylin Muskat, April Frazier, Yaqian Xu, José Mateus, Alba Grifoni, Ricardo da Silva Antunes, Daniela Weiskopf, Amy W. Amara, David G. Standaert, Jennifer G. Goldman, Irene Litvan, Roy N. Alcalay, David Sulzer, Cecilia S. Lindestam Arlehamn, Alessandro Sette
bioRxiv 2022.04.05.487195; doi: https://doi.org/10.1101/2022.04.05.487195

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Immunology
Subject Areas
All Articles
  • Animal Behavior and Cognition (3609)
  • Biochemistry (7585)
  • Bioengineering (5533)
  • Bioinformatics (20825)
  • Biophysics (10344)
  • Cancer Biology (7995)
  • Cell Biology (11653)
  • Clinical Trials (138)
  • Developmental Biology (6617)
  • Ecology (10224)
  • Epidemiology (2065)
  • Evolutionary Biology (13639)
  • Genetics (9557)
  • Genomics (12856)
  • Immunology (7930)
  • Microbiology (19568)
  • Molecular Biology (7675)
  • Neuroscience (42182)
  • Paleontology (308)
  • Pathology (1259)
  • Pharmacology and Toxicology (2208)
  • Physiology (3271)
  • Plant Biology (7058)
  • Scientific Communication and Education (1295)
  • Synthetic Biology (1953)
  • Systems Biology (5433)
  • Zoology (1119)