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A subtype of melanopsin ganglion cells encodes ground luminance

Michael H. Berry, Michael Moldavan, Tavita Garrett, Marc Meadows, Olga Cravetchi, Elizabeth White, Henrique von Gersdorff, Kevin M Wright, Charles Allen, View ORCID ProfileBenjamin Sivyer
doi: https://doi.org/10.1101/2022.04.06.485949
Michael H. Berry
1Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, OR, 97239
2Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR, 97239
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Michael Moldavan
3Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, 97239
4Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, 97239
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Tavita Garrett
1Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, OR, 97239
5Neuroscience Graduate program, Oregon Health & Science University, Portland, OR, 97239
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Marc Meadows
5Neuroscience Graduate program, Oregon Health & Science University, Portland, OR, 97239
6Vollum Institute, Oregon Health & Science University, Portland, OR, 97239
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Olga Cravetchi
3Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, 97239
4Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, 97239
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Elizabeth White
1Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, OR, 97239
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Henrique von Gersdorff
1Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, OR, 97239
2Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR, 97239
6Vollum Institute, Oregon Health & Science University, Portland, OR, 97239
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Kevin M Wright
6Vollum Institute, Oregon Health & Science University, Portland, OR, 97239
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Charles Allen
3Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, 97239
4Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, 97239
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Benjamin Sivyer
1Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, OR, 97239
2Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR, 97239
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  • ORCID record for Benjamin Sivyer
  • For correspondence: sivyer@ohsu.edu
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Abstract

Visual input to the hypothalamus from intrinsically photosensitive retinal ganglion cells (ipRGCs) influences several functions including circadian entrainment, body temperature, and sleep. ipRGCs also project to nuclei such as the supraoptic nucleus (SON), which is involved in systemic fluid homeostasis, maternal behavior, and appetite. However, little is known about the SON-projecting ipRGCs or their relationship to well-characterized ipRGC subtypes. Using a GlyT2Cre mouse line, we identify a subtype of ipRGCs restricted to the dorsal retina that selectively project to the SON. These ipRGCs form a non-overlapping tiled mosaic that is limited to a dorsal region of the retina, forming a substrate for encoding ground luminance. Optogenetic activation of their axons demonstrates they release the neurotransmitter glutamate and that the SON is retinorecipient, receiving synaptic input from dorsal ipRGCs. Our results challenge the idea that ipRGC dendrites overlap to optimize photon capture and suggests non-image forming vision operates to sample local regions of the visual field.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted April 10, 2022.
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A subtype of melanopsin ganglion cells encodes ground luminance
Michael H. Berry, Michael Moldavan, Tavita Garrett, Marc Meadows, Olga Cravetchi, Elizabeth White, Henrique von Gersdorff, Kevin M Wright, Charles Allen, Benjamin Sivyer
bioRxiv 2022.04.06.485949; doi: https://doi.org/10.1101/2022.04.06.485949
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A subtype of melanopsin ganglion cells encodes ground luminance
Michael H. Berry, Michael Moldavan, Tavita Garrett, Marc Meadows, Olga Cravetchi, Elizabeth White, Henrique von Gersdorff, Kevin M Wright, Charles Allen, Benjamin Sivyer
bioRxiv 2022.04.06.485949; doi: https://doi.org/10.1101/2022.04.06.485949

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