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Caenorhabditis elegans MES-3 is a highly divergent ortholog of the canonical PRC2 component SUZ12

View ORCID ProfileBerend Snel, Sander van den Heuvel, Michael F. Seidl
doi: https://doi.org/10.1101/2022.04.07.487461
Berend Snel
1Theoretical Biology & Bioinformatics, Department of Biology, Faculty of Science, University, Utrecht, Padualaan 8, 3584 CH Utrecht, the Netherlands
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  • ORCID record for Berend Snel
Sander van den Heuvel
2Developmental Biology, Department of Biology, Faculty of Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands
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Michael F. Seidl
1Theoretical Biology & Bioinformatics, Department of Biology, Faculty of Science, University, Utrecht, Padualaan 8, 3584 CH Utrecht, the Netherlands
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  • For correspondence: m.f.seidl@uu.nl
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SUMMARY

Polycomb Repressive Complex 2 (PRC2) catalyzes the mono-, di, and trimethylation of histone protein H3 on lysine 27 (H3K27), which is strongly associated with transcriptionally silent chromatin. The functional core of PRC2 is highly conserved in animals and consists of four subunits. One of these, SUZ12, has not been identified in the genetic model Caenorhabditis elegans, whereas C. elegans PRC2 contains the clade-specific MES-3 protein. Through unbiased sensitive sequence similarity searches complemented by high-quality structure predictions of monomers and multimers, we here demonstrate that MES-3 is a highly divergent ortholog of SUZ12. MES-3 shares protein folds and conserved residues of key domains with SUZ12 and is predicted to interact with core PRC2 members similar to SUZ12 in human PRC2. Thus, in agreement with previous genetic and biochemical studies, we provide evidence that C. elegans contains a diverged yet evolutionary conserved core PRC2, like other animals.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted May 27, 2022.
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Caenorhabditis elegans MES-3 is a highly divergent ortholog of the canonical PRC2 component SUZ12
Berend Snel, Sander van den Heuvel, Michael F. Seidl
bioRxiv 2022.04.07.487461; doi: https://doi.org/10.1101/2022.04.07.487461
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Caenorhabditis elegans MES-3 is a highly divergent ortholog of the canonical PRC2 component SUZ12
Berend Snel, Sander van den Heuvel, Michael F. Seidl
bioRxiv 2022.04.07.487461; doi: https://doi.org/10.1101/2022.04.07.487461

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