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DOT1L activity affects cell lineage progression in the developing brain by controlling metabolic programs

Bismark Appiah, Camilla L. Fullio, Christiane Haffner, Patrice Zeis, Martin Treppner, Patrick Bovio, Arquimedes Cheffer, Ilaria Bertani, Harald Binder, Dominic Grün, View ORCID ProfileNereo Kalebic, Elena Taverna, View ORCID ProfileTanja Vogel
doi: https://doi.org/10.1101/2022.04.08.487591
Bismark Appiah
1Institute of Anatomy and Cell Biology, Department of Molecular Embryology, Faculty of Medicine, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany
2Faculty of Biology, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany
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Camilla L. Fullio
1Institute of Anatomy and Cell Biology, Department of Molecular Embryology, Faculty of Medicine, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany
2Faculty of Biology, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany
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Christiane Haffner
3Max Planck Institute for Molecular Cell Biology and Genetics, 01307 Dresden, Germany
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Patrice Zeis
2Faculty of Biology, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany
4Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany
5International Max Planck Research School for Molecular and Cellular Biology (IMPRS-MCB), Freiburg, Germany
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Martin Treppner
2Faculty of Biology, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany
6Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany
7Freiburg Center for Data Analysis and Modeling, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany
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Patrick Bovio
1Institute of Anatomy and Cell Biology, Department of Molecular Embryology, Faculty of Medicine, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany
2Faculty of Biology, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany
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Arquimedes Cheffer
1Institute of Anatomy and Cell Biology, Department of Molecular Embryology, Faculty of Medicine, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany
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Ilaria Bertani
8Human Technopole, 20157 Milan, Italy
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Harald Binder
6Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany
7Freiburg Center for Data Analysis and Modeling, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany
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Dominic Grün
4Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany
9Würzburg Institute of Systems Immunology, Julius-Maximilians-University Würzburg, 97078 Würzburg, Germany
10Centre for Integrative Biological Signaling Studies, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany
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Nereo Kalebic
8Human Technopole, 20157 Milan, Italy
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  • ORCID record for Nereo Kalebic
Elena Taverna
8Human Technopole, 20157 Milan, Italy
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  • For correspondence: tanja.vogel@anat.uni-freiburg.de
Tanja Vogel
1Institute of Anatomy and Cell Biology, Department of Molecular Embryology, Faculty of Medicine, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany
11Center for Basics in NeuroModulation (NeuroModul Basics), Medical Faculty, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany
12Freiburg Institute for Advanced Studies (FRIAS), Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany
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  • ORCID record for Tanja Vogel
  • For correspondence: tanja.vogel@anat.uni-freiburg.de
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Article Information

doi 
https://doi.org/10.1101/2022.04.08.487591
History 
  • April 12, 2022.

Article Versions

  • Version 1 (April 8, 2022 - 14:38).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Bismark Appiah1,2,
  2. Camilla L. Fullio1,2,
  3. Christiane Haffner3,
  4. Patrice Zeis2,4,5,
  5. Martin Treppner2,6,7,
  6. Patrick Bovio1,2,
  7. Arquimedes Cheffer1,
  8. Ilaria Bertani8,
  9. Harald Binder6,7,
  10. Dominic Grün4,9,10,
  11. Nereo Kalebic8,
  12. Elena Taverna8,* and
  13. Tanja Vogel1,11,12,*
  1. 1Institute of Anatomy and Cell Biology, Department of Molecular Embryology, Faculty of Medicine, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany
  2. 2Faculty of Biology, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany
  3. 3Max Planck Institute for Molecular Cell Biology and Genetics, 01307 Dresden, Germany
  4. 4Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany
  5. 5International Max Planck Research School for Molecular and Cellular Biology (IMPRS-MCB), Freiburg, Germany
  6. 6Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany
  7. 7Freiburg Center for Data Analysis and Modeling, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany
  8. 8Human Technopole, 20157 Milan, Italy
  9. 9Würzburg Institute of Systems Immunology, Julius-Maximilians-University Würzburg, 97078 Würzburg, Germany
  10. 10Centre for Integrative Biological Signaling Studies, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany
  11. 11Center for Basics in NeuroModulation (NeuroModul Basics), Medical Faculty, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany
  12. 12Freiburg Institute for Advanced Studies (FRIAS), Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany
  1. ↵* shared corresponding authors, email: tanja.vogel{at}anat.uni-freiburg.de
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DOT1L activity affects cell lineage progression in the developing brain by controlling metabolic programs
Bismark Appiah, Camilla L. Fullio, Christiane Haffner, Patrice Zeis, Martin Treppner, Patrick Bovio, Arquimedes Cheffer, Ilaria Bertani, Harald Binder, Dominic Grün, Nereo Kalebic, Elena Taverna, Tanja Vogel
bioRxiv 2022.04.08.487591; doi: https://doi.org/10.1101/2022.04.08.487591
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DOT1L activity affects cell lineage progression in the developing brain by controlling metabolic programs
Bismark Appiah, Camilla L. Fullio, Christiane Haffner, Patrice Zeis, Martin Treppner, Patrick Bovio, Arquimedes Cheffer, Ilaria Bertani, Harald Binder, Dominic Grün, Nereo Kalebic, Elena Taverna, Tanja Vogel
bioRxiv 2022.04.08.487591; doi: https://doi.org/10.1101/2022.04.08.487591

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