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Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions
View ORCID ProfileYu Zhao, Camila Coelho, Amanda L. Hughes, Luciana Lazar-Stefanita, Sandy Yang, Aaron N. Brooks, View ORCID ProfileRoy S. K. Walker, Weimin Zhang, View ORCID ProfileStephanie Lauer, Cindy Hernandez, Leslie A. Mitchell, View ORCID ProfileNeta Agmon, Yue Shen, Joseph Sall, Viola Fanfani, Anavi Jalan, Jordan Rivera, Feng-Xia Liang, Giovanni Stracquadanio, Lars M. Steinmetz, Yizhi Patrick Cai, View ORCID ProfileJef D. Boeke
doi: https://doi.org/10.1101/2022.04.11.486913
Yu Zhao
1Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016, USA
Camila Coelho
1Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016, USA
Amanda L. Hughes
2European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany
Luciana Lazar-Stefanita
1Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016, USA
Sandy Yang
1Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016, USA
Aaron N. Brooks
2European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany
Roy S. K. Walker
3School of Engineering, Institute for Bioengineering, The University of Edinburgh, Edinburgh EH9 3BF
Weimin Zhang
1Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016, USA
Stephanie Lauer
1Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016, USA
Cindy Hernandez
1Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016, USA
Leslie A. Mitchell
1Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016, USA
Neta Agmon
1Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016, USA
Yue Shen
4School of Biological Sciences, The University of Edinburgh, Edinburgh, EH9 3BF, UK
5BGI-Shenzhen, Beishan Industrial Zone, Shenzhen 518083, China
6Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen, 518120, China
Joseph Sall
7Microscopy Laboratory, NYU Langone Health, New York, NY, 10016 USA
Viola Fanfani
4School of Biological Sciences, The University of Edinburgh, Edinburgh, EH9 3BF, UK
Anavi Jalan
8Department of Biology, NYU, New York, NY, USA
Jordan Rivera
8Department of Biology, NYU, New York, NY, USA
Feng-Xia Liang
7Microscopy Laboratory, NYU Langone Health, New York, NY, 10016 USA
Giovanni Stracquadanio
4School of Biological Sciences, The University of Edinburgh, Edinburgh, EH9 3BF, UK
Lars M. Steinmetz
2European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany
9Department of Genetics and Stanford Genome Technology Center, Stanford University, Palo Alto, CA 94304, USA
Yizhi Patrick Cai
4School of Biological Sciences, The University of Edinburgh, Edinburgh, EH9 3BF, UK
Jef D. Boeke
1Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016, USA
10Department of Biomedical Engineering, NYU Tandon School of Engineering, Brooklyn, NY, USA
Article usage
Posted April 11, 2022.
Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions
Yu Zhao, Camila Coelho, Amanda L. Hughes, Luciana Lazar-Stefanita, Sandy Yang, Aaron N. Brooks, Roy S. K. Walker, Weimin Zhang, Stephanie Lauer, Cindy Hernandez, Leslie A. Mitchell, Neta Agmon, Yue Shen, Joseph Sall, Viola Fanfani, Anavi Jalan, Jordan Rivera, Feng-Xia Liang, Giovanni Stracquadanio, Lars M. Steinmetz, Yizhi Patrick Cai, Jef D. Boeke
bioRxiv 2022.04.11.486913; doi: https://doi.org/10.1101/2022.04.11.486913
Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions
Yu Zhao, Camila Coelho, Amanda L. Hughes, Luciana Lazar-Stefanita, Sandy Yang, Aaron N. Brooks, Roy S. K. Walker, Weimin Zhang, Stephanie Lauer, Cindy Hernandez, Leslie A. Mitchell, Neta Agmon, Yue Shen, Joseph Sall, Viola Fanfani, Anavi Jalan, Jordan Rivera, Feng-Xia Liang, Giovanni Stracquadanio, Lars M. Steinmetz, Yizhi Patrick Cai, Jef D. Boeke
bioRxiv 2022.04.11.486913; doi: https://doi.org/10.1101/2022.04.11.486913
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