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Neural instructive signals for associative cerebellar learning

View ORCID ProfileN. Tatiana Silva, View ORCID ProfileJorge Ramírez-Buriticá, View ORCID ProfileDominique L. Pritchett, View ORCID ProfileMegan R. Carey
doi: https://doi.org/10.1101/2022.04.18.488634
N. Tatiana Silva
1Neuroscience Program, Champalimaud Center for the Unknown, Lisbon Portugal
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Jorge Ramírez-Buriticá
1Neuroscience Program, Champalimaud Center for the Unknown, Lisbon Portugal
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Dominique L. Pritchett
1Neuroscience Program, Champalimaud Center for the Unknown, Lisbon Portugal
2Biology Dept., Howard University, Washington D.C
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  • For correspondence: megan.carey@neuro.fchampalimaud.org dominique.pritchett@howard.edu
Megan R. Carey
1Neuroscience Program, Champalimaud Center for the Unknown, Lisbon Portugal
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  • For correspondence: megan.carey@neuro.fchampalimaud.org dominique.pritchett@howard.edu
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ABSTRACT

Supervised learning depends on instructive signals that shape the output of neural circuits to support learned changes in behavior. Climbing fiber inputs to the cerebellar cortex represent one of the strongest candidates in the vertebrate brain for conveying neural instructive signals. However, recent studies have shown that Purkinje cell stimulation can also drive cerebellar learning, and the relative importance of these two neuron types in providing instructive signals for cerebellum-dependent behaviors remains unresolved. Here we used cell-type specific perturbations of climbing fibers, Purkinje cells, and other cerebellar circuit elements to systematically evaluate their contributions to delay eyeblink conditioning. Our findings reveal that while optogenetic stimulation of either climbing fibers or Purkinje cells can substitute for a sensory unconditioned stimulus, subtle reductions in climbing fiber signaling prevent learning entirely. We conclude that climbing fibers and corresponding Purkinje cell complex-spike events provide essential instructive signals for associative cerebellar learning.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • COMPETING INTERESTS The authors declare no competing financial interests.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted April 18, 2022.
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Neural instructive signals for associative cerebellar learning
N. Tatiana Silva, Jorge Ramírez-Buriticá, Dominique L. Pritchett, Megan R. Carey
bioRxiv 2022.04.18.488634; doi: https://doi.org/10.1101/2022.04.18.488634
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Neural instructive signals for associative cerebellar learning
N. Tatiana Silva, Jorge Ramírez-Buriticá, Dominique L. Pritchett, Megan R. Carey
bioRxiv 2022.04.18.488634; doi: https://doi.org/10.1101/2022.04.18.488634

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