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A genotoxic antibody drug conjugate targeting CD276/B7H3 demonstrates efficacy across multiple biomarker defined classes of treatment refractory metastatic prostate cancer
View ORCID ProfileSupreet Agarwal, Lei Fang, Kerry McGowen, JuanJuan Yin, Joel Bowman, Anson T. Ku, Aian Neil Alilin, Eva Corey, Martine Roudier, Lawrence True, Ruthy Dumpit, Ilsa Coleman, John Lee, Peter S. Nelson, Brian J. Capaldo, Ilya S. Senatorov, Adam G. Sowalsky, Elaine M Hurt, Kathleen Kelly
doi: https://doi.org/10.1101/2022.04.19.488784
Supreet Agarwal
1Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, NIH; Bethesda, Maryland, USA.
Lei Fang
1Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, NIH; Bethesda, Maryland, USA.
Kerry McGowen
1Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, NIH; Bethesda, Maryland, USA.
JuanJuan Yin
1Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, NIH; Bethesda, Maryland, USA.
Joel Bowman
1Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, NIH; Bethesda, Maryland, USA.
Anson T. Ku
1Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, NIH; Bethesda, Maryland, USA.
Aian Neil Alilin
1Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, NIH; Bethesda, Maryland, USA.
Eva Corey
2Department of Urology, University of Washington, Seattle, WA 98195
Martine Roudier
2Department of Urology, University of Washington, Seattle, WA 98195
Lawrence True
3Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195
Ruthy Dumpit
4Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98119
Ilsa Coleman
4Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98119
John Lee
4Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98119
Peter S. Nelson
4Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98119
Brian J. Capaldo
1Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, NIH; Bethesda, Maryland, USA.
Ilya S. Senatorov
1Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, NIH; Bethesda, Maryland, USA.
Adam G. Sowalsky
1Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, NIH; Bethesda, Maryland, USA.
Elaine M Hurt
5AstraZeneca; Gaithersburg, Maryland, USA.
Kathleen Kelly
1Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, NIH; Bethesda, Maryland, USA.
Posted April 20, 2022.
A genotoxic antibody drug conjugate targeting CD276/B7H3 demonstrates efficacy across multiple biomarker defined classes of treatment refractory metastatic prostate cancer
Supreet Agarwal, Lei Fang, Kerry McGowen, JuanJuan Yin, Joel Bowman, Anson T. Ku, Aian Neil Alilin, Eva Corey, Martine Roudier, Lawrence True, Ruthy Dumpit, Ilsa Coleman, John Lee, Peter S. Nelson, Brian J. Capaldo, Ilya S. Senatorov, Adam G. Sowalsky, Elaine M Hurt, Kathleen Kelly
bioRxiv 2022.04.19.488784; doi: https://doi.org/10.1101/2022.04.19.488784
A genotoxic antibody drug conjugate targeting CD276/B7H3 demonstrates efficacy across multiple biomarker defined classes of treatment refractory metastatic prostate cancer
Supreet Agarwal, Lei Fang, Kerry McGowen, JuanJuan Yin, Joel Bowman, Anson T. Ku, Aian Neil Alilin, Eva Corey, Martine Roudier, Lawrence True, Ruthy Dumpit, Ilsa Coleman, John Lee, Peter S. Nelson, Brian J. Capaldo, Ilya S. Senatorov, Adam G. Sowalsky, Elaine M Hurt, Kathleen Kelly
bioRxiv 2022.04.19.488784; doi: https://doi.org/10.1101/2022.04.19.488784
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