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Prefusion-Stabilized Lassa Virus Trimer Identifies Neutralizing Nanobodies and Reveals an Apex-Situated Site of Vulnerability
Jason Gorman, Crystal Sao-Fong Cheung, Zhijian Duan, Yaping Sun, Pengfei Wang, Jeffrey C. Boyington, Andrea Biju, Tatsiana Bylund, Cheng Cheng, Li Ou, Tyler Stephens, Yaroslav Tsybovsky, Raffaello Verardi, Shuishu Wang, Yongping Yang, Baoshan Zhang, ChengYan Zheng, Tongqing Zhou, John R. Mascola, David D. Ho, View ORCID ProfileMitchell Ho, Peter D. Kwong
doi: https://doi.org/10.1101/2022.04.21.488985
Jason Gorman
aVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA
Crystal Sao-Fong Cheung
aVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA
Zhijian Duan
bNCI Antibody Engineering Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Yaping Sun
bNCI Antibody Engineering Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Pengfei Wang
cAaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032
Jeffrey C. Boyington
aVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA
Andrea Biju
aVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA
Tatsiana Bylund
aVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA
Cheng Cheng
aVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA
Li Ou
aVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA
Tyler Stephens
dElectron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
Yaroslav Tsybovsky
dElectron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
Raffaello Verardi
aVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA
Shuishu Wang
aVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA
Yongping Yang
aVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA
Baoshan Zhang
aVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA
ChengYan Zheng
aVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA
Tongqing Zhou
aVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA
John R. Mascola
aVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA
David D. Ho
cAaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032
Mitchell Ho
bNCI Antibody Engineering Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Peter D. Kwong
aVaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA
Posted April 21, 2022.
Prefusion-Stabilized Lassa Virus Trimer Identifies Neutralizing Nanobodies and Reveals an Apex-Situated Site of Vulnerability
Jason Gorman, Crystal Sao-Fong Cheung, Zhijian Duan, Yaping Sun, Pengfei Wang, Jeffrey C. Boyington, Andrea Biju, Tatsiana Bylund, Cheng Cheng, Li Ou, Tyler Stephens, Yaroslav Tsybovsky, Raffaello Verardi, Shuishu Wang, Yongping Yang, Baoshan Zhang, ChengYan Zheng, Tongqing Zhou, John R. Mascola, David D. Ho, Mitchell Ho, Peter D. Kwong
bioRxiv 2022.04.21.488985; doi: https://doi.org/10.1101/2022.04.21.488985
Prefusion-Stabilized Lassa Virus Trimer Identifies Neutralizing Nanobodies and Reveals an Apex-Situated Site of Vulnerability
Jason Gorman, Crystal Sao-Fong Cheung, Zhijian Duan, Yaping Sun, Pengfei Wang, Jeffrey C. Boyington, Andrea Biju, Tatsiana Bylund, Cheng Cheng, Li Ou, Tyler Stephens, Yaroslav Tsybovsky, Raffaello Verardi, Shuishu Wang, Yongping Yang, Baoshan Zhang, ChengYan Zheng, Tongqing Zhou, John R. Mascola, David D. Ho, Mitchell Ho, Peter D. Kwong
bioRxiv 2022.04.21.488985; doi: https://doi.org/10.1101/2022.04.21.488985
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