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Spt4 drives cellular senescence by activating non-coding RNA transcription in ribosomal RNA gene clusters

Masaaki Yokoyama, Mariko Sasaki, View ORCID ProfileTakehiko Kobayashi
doi: https://doi.org/10.1101/2022.04.22.488906
Masaaki Yokoyama
1Laboratory of Genome Regeneration, Institute for Quantitative Biosciences (IQB), The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, JAPAN
2Department of Biological Sciences, Graduate School of Science, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, JAPAN
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Mariko Sasaki
1Laboratory of Genome Regeneration, Institute for Quantitative Biosciences (IQB), The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, JAPAN
2Department of Biological Sciences, Graduate School of Science, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, JAPAN
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  • For correspondence: sasakim@iqb.u-tokyo.ac.jp tako2015@iqb.u-tokyo.ac.jp
Takehiko Kobayashi
1Laboratory of Genome Regeneration, Institute for Quantitative Biosciences (IQB), The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, JAPAN
2Department of Biological Sciences, Graduate School of Science, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, JAPAN
3Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, JAPAN
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  • ORCID record for Takehiko Kobayashi
  • For correspondence: sasakim@iqb.u-tokyo.ac.jp tako2015@iqb.u-tokyo.ac.jp
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Article Information

doi 
https://doi.org/10.1101/2022.04.22.488906
History 
  • April 22, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

  1. Masaaki Yokoyama1,2,
  2. Mariko Sasaki1,2,4 and
  3. Takehiko Kobayashi1,2,3,4
  1. 1Laboratory of Genome Regeneration, Institute for Quantitative Biosciences (IQB), The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, JAPAN
  2. 2Department of Biological Sciences, Graduate School of Science, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, JAPAN
  3. 3Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, JAPAN
  1. ↵4Correspondence to: sasakim{at}iqb.u-tokyo.ac.jp, tako2015{at}iqb.u-tokyo.ac.jp (lead contact)
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Posted April 22, 2022.
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Spt4 drives cellular senescence by activating non-coding RNA transcription in ribosomal RNA gene clusters
Masaaki Yokoyama, Mariko Sasaki, Takehiko Kobayashi
bioRxiv 2022.04.22.488906; doi: https://doi.org/10.1101/2022.04.22.488906
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Spt4 drives cellular senescence by activating non-coding RNA transcription in ribosomal RNA gene clusters
Masaaki Yokoyama, Mariko Sasaki, Takehiko Kobayashi
bioRxiv 2022.04.22.488906; doi: https://doi.org/10.1101/2022.04.22.488906

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